Abstract
Long-term survival of patients with histologically confirmed glioblastoma is a rare event with figures in the range of 2–3% for 5-year survival (Scott et al. in Ann Neurol 46:183-188, 1999; McLendon and Halperin in Cancer 98:1745-1748, 2003; Krex et al. in Brain 130:2596-2606, 2007). Prognosis and further clinical course of these patients beyond 5 years after diagnosis are in essence unknown with only anecdotal reports of patients surviving for 10 years or more (Salvati et al. J Neurooncol 36:61-64, 1998). We here report on the extended follow-up (mean, 139.4 months) of a cohort of glioblastoma long-term survivors. Very late relapses occurred in many patients even after more than 10 years of progression-free survival.
This is a preview of subscription content, log in via an institution to check access.
References
Scott JN, Rewcastle NB, Brasher PM et al (1999) Which glioblastoma multiforme patient will become a long-term survivor? A population-based study. Ann Neurol 46:183–188. doi:10.1002/1531-8249(199908)46:2<183::AID-ANA7>3.0.CO;2-7
McLendon RE, Halperin EC (2003) Is the long-term survival of patients with intracranial glioblastoma multiforme overstated? Cancer 98:1745–1748. doi:10.1002/cncr.11666
Krex D, Klink B, Hartmann C et al (2007) Long-term survival with glioblastoma multiforme. Brain 130:2596–2606. doi:10.1093/brain/awm204
Salvati M, Cervoni L, Artico M et al (1998) Long-term survival in patients with supratentorial glioblastoma. J Neurooncol 36:61–64. doi:10.1023/A:1017926603341
Steinbach JP, Blaicher H-P, Herrlinger U et al (2006) Surviving glioblastoma for more than 5 years: the patient’s perspective. Neurology 66:239–242. doi:10.1212/01.wnl.0000194221.89948.a0
Acknowledgment
This study was supported by the Jaqueline Seroussi Memorial Foundation. The Dr. Senckenberg Institute of Neurooncology is supported by the Senckenberg Foundation and the Hertie Foundation. JS is a Hertie-Professor for Neurooncology. We thank Susanne Nussbaum for help with data acquisition.
Conflict of interest statement
The authors report no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bähr, O., Herrlinger, U., Weller, M. et al. Very late relapses in glioblastoma long-term survivors. J Neurol 256, 1756–1758 (2009). https://doi.org/10.1007/s00415-009-5167-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-009-5167-6