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Expression of podoplanin in Warthin tumours

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Abstract

Purpose

Warthin tumour is the second most common benign tumour of the parotid gland. This study was designed to investigate the lymphatic vessels in Warthin tumours in an effort to understand better its pathogenesis.

Materials and methods

Tissue specimens of 31 patients (19 men and 11 women; mean age 57 years, median size of the tumours 2.86 cm) were analysed by means of immunohistochemistry applying the monoclonal antibody D2-40.

Results

We found numerous D2-40-positive sinus-like vessels particularly at the inner layer of the capsule.

Conclusions

Since subcapsular sinuses are a major morphological feature of lymph nodes in general, the finding of podoplanin expression in the large majority of subcapsular vessels in Warthin tumours confirms the view that this tumour has its origin in regional lymph nodes.

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References

  1. Ellis GL, Auclair PL (2008) Tumors of the salivary gland. American Registry of Pathology, Washington

    Google Scholar 

  2. Teymoortash A, Schrader C, Shimoda H, Kato S, Werner JA (2007) Evidence of lymphangiogenesis in Warthin’s tumor of the parotid gland. Oral Oncol 43:614–618

    Article  CAS  PubMed  Google Scholar 

  3. Seifert G, Bull HG, Donath K (1980) Histologic subclassification of the cystadenolymphoma of the parotid gland. Virchows Arch A Path Anat and Histol 388:13–38

    Article  CAS  Google Scholar 

  4. Kaiserling E (2004) Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology. Pathologe 25:362–374

    Article  CAS  PubMed  Google Scholar 

  5. Fukunaga M (2005) Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumors. Histopathology 46:396–402

    Article  CAS  PubMed  Google Scholar 

  6. Hansen T, Katenkamp K, Bittinger F, Kirkpatrick CJ, Katenkamp D (2007) D2-40 labelling in lymphangiomyoma/lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis. Virchows Arch 450:449–453

    Article  PubMed  Google Scholar 

  7. Hata M, Ueki T, Sato A, Kojima H, Sawa Y (2008) Expression of podoplanin in the mouse salivary glands. Arch Oral Biol 53:835–841

    Article  CAS  PubMed  Google Scholar 

  8. Kanner WA, Galgano MT, Atkins KA (2010) Podoplanin expression in basal and myoepithelial cells: utility and potential pitfalls. Appl Immunhistochem Mol Morphol (in press)

  9. van der Valk P, Meijer CJLM (1997) Reactive lymph nodes. In: Sternberg SS (ed) Histology for pathologists, 2nd edn. Lippincott-Raven, Philadelphia

    Google Scholar 

  10. Soma L, LiVolsi VA, Baloch ZW (2001) Dendritic interstitial and myofibroblastic cells at the border of salivary gland tumors. Arch Pathol Lab Med 125:232–236

    CAS  PubMed  Google Scholar 

  11. Schwerer MJ, Kraft K, Baczako K, Maier H (2001) Cytokeratin expression and epithelial differentiation in Warthin’s tumor and its metaplastic (infracted) variant. Histopathology 39:347–352

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgement

We thank Mrs. Irmtrud Roth (Institute of Pathology, University of Mainz) for her expert technical assistance.

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Authors and Affiliations

  1. Institute of Pathology, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55101, Mainz, Germany

    Torsten Hansen & C. James Kirkpatrick

Authors
  1. Torsten Hansen
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  2. C. James Kirkpatrick
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Correspondence to Torsten Hansen.

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Hansen, T., Kirkpatrick, C.J. Expression of podoplanin in Warthin tumours. Oral Maxillofac Surg 14, 223–226 (2010). https://doi.org/10.1007/s10006-010-0226-9

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  • DOI: https://doi.org/10.1007/s10006-010-0226-9

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