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Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas

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Abstract

Our purpose was to investigate whether in vivo proton magnetic resonance spectroscopic imaging, using normalized concentrations of total choline (tCho) and total creatine (tCr), can differentiate between WHO grade I pilocytic astrocytoma (PA) and diffuse, fibrillary WHO grade II astrocytoma (DA) in children. Data from 16 children with astrocytomas (11 children with PA and 5 children with DA) were evaluated retrospectively. MRS was performed before treatment in all patients with histologically proven low-grade astrocytomas. Metabolite concentrations of tCho and tCr were normalized to the respective concentration in contralateral brain tissue. The Mann-Whitney U test was performed to evaluate differences between these two groups. Normalized tCho did not show any statistically significant difference between the two groups. There was a strong trend (P = 0.07) toward higher values of normalized tCr in the DA group. For 3 of 5 children with DA, lactate was detectable, but only 1 of 11 children with PA showed lactate. We concluded that choline as a single parameter is not reliable in the differential diagnosis of low-grade astrocytomas in children. Our results suggest that tCr concentrations combined with lactate will be helpful in the differential diagnosis of PA and DA in children.

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Authors and Affiliations

  1. Neuroradiology Department, Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universität, Schleusenweg 2-16, D-60528, Frankfurt am Main, Germany

    Luciana Porto, Kea Franz, Ulrich Pilatus & Elke Hattingen

  2. Neuropediatric Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

    Matthias Kieslich

  3. Pediatric Haematology/Oncology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

    Thomas Lehrbecher

Authors
  1. Luciana Porto
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  2. Matthias Kieslich
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  3. Kea Franz
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  4. Thomas Lehrbecher
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  5. Ulrich Pilatus
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  6. Elke Hattingen
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Correspondence to Luciana Porto.

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Porto, L., Kieslich, M., Franz, K. et al. Proton magnetic resonance spectroscopic imaging in pediatric low-grade gliomas. Brain Tumor Pathol 27, 65–70 (2010). https://doi.org/10.1007/s10014-010-0268-6

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  • DOI: https://doi.org/10.1007/s10014-010-0268-6

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