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Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity

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Abstract

T follicular helper (Tfh) cells are a subset of effector CD4+ T cells specialised to induce Ab production by B cells. This review highlights some of the recent advances in the field of human Tfh cells that have come from the study of primary immunodeficiencies. In particular it is increasingly evident that the quality of the Tfh cells that are generated, is just as important as the quantity.

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Acknowledgments

I would like to thank Prof. Stuart Tangye for his critical review of this manuscript. The author is supported by fellowship and grants from the NH&MRC of Australia (1008820; 596813; 1008558; 1060303).

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  1. Immunology Division, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia

    Cindy S. Ma

  2. St Vincent’s Clinical School, University of New South Wales, Kensington, NSW, 2052, Australia

    Cindy S. Ma

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Correspondence to Cindy S. Ma.

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C.S.M has received a speaker honorarium from Baxalta.

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Ma, C.S. Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity. J Clin Immunol 36 (Suppl 1), 40–47 (2016). https://doi.org/10.1007/s10875-016-0257-6

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