Abstract
Deprescribing is a holistic process of medication cessation that encompasses gaining a comprehensive medication list, identifying potentially inappropriate medications, deciding if the identified medication can be ceased, planning the withdrawal regimen and monitoring, support and follow-up. It is currently being investigated as a mechanism to reduce unnecessary or redundant medications. However, given the systematic and patient-centred nature of the deprescribing process, it is possible that it may also confer additional benefits such as improving adherence to medications, even if there is no net reduction in overall medication use. Specifically, deprescribing may improve adherence via reducing polypharmacy, reducing the financial costs associated with medication taking, increasing the patient’s medication knowledge through education, increasing patient engagement in medication management and resolution of adverse drug reactions. More research into deprescribing must be conducted to establish if these potential benefits can be realised, in addition to establishing any negative consequences.
References
Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5:345–51.
Woodward M. Deprescribing : achieving better health outcomes for older people through reducing medications. J Pharm Pract Res. 2003;33:323–8.
Le Couteur DG, Banks E, Gnjidic D, McLachlan A. Deprescribing. Australian Prescriber. 2011;34:182–5.
Hardy JE, Hilmer SN. Deprescribing in the last year of life. J Pharm Pract Res. 2011;41:146–51.
Bain KT, Holmes HM, Beers MH, Maio V, Handler SM, Pauker SG. Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process. J Am Geriatr Soc. 2008;56:1946–52.
Scott I, Gray L, Martin J, Mitchell C. Minimizing inappropriate medications in older populations: a 10-step conceptual framework. Am J Med. 2012;125:529–37.
Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487–97.
Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. J Clin Pharm Ther. 2002;26:331–42.
Shoemaker SJ, de Oliveira DR. Understanding the meaning of medications for patients: the medication experience. Pharm World Sci. 2008;30:86–91.
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. The Cochrane Library. 2008;2:CD000011.
Barat I, Andreasen F, Damsgaard EM. Drug therapy in the elderly: what doctors believe and patients actually do. Br J Clin Pharmacol. 2001;51:615–22.
Chapman RH, Benner JS, Petrilla AA, Tierce JC, Collins R, Battleman DS, et al. Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med. 2005;165:1147–52.
Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001;23:1296–310.
Nichols-English G, Poirier S. Optimizing adherence to pharmaceutical care plans. J Am Pharm Assoc. 2000;40:475–85.
Dolovich L, Nair K, Sellors C, Lohfeld L, Lee A, Levine M. Do patients’ expectations influence their use of medications? Qualitative study. Can Fam Physician. 2008;54:384–93.
Safran DG, Neuman P, Schoen C, Montgomery JE, Li W, Wilson IB, et al. Prescription drug coverage and seniors: how well are states closing the gap? Health Aff (Millwood). 2002;21:W253–68.
Reeve E, Wiese MD, Hendrix I, Roberts M, Shakib S. People’s attitudes, beliefs, and experiences regarding polypharmacy and willingness to deprescribe. J Am Geriatr Soc. 2013;61:1508–14.
Williams A, Manias E, Walker R. Interventions to improve medication adherence in people with multiple chronic conditions: a systematic review. J Adv Nurs. 2008;63:132–43.
Horne R, Weinman J. Patients’ beliefs about prescribed medicines and their role in adherence to treatment in chronic physical illness. J Psychosom Res. 1999;47:555–67.
Byrne M, Walsh J, Murphy AW. Secondary prevention of coronary heart disease: patient beliefs and health-related behaviour. J Psychosom Res. 2005;58:403–15.
Conn VS, Hafdahl AR, Cooper PS, Ruppar TM, Mehr DR, Russell CL. Interventions to improve medication adherence among older adults: meta-analysis of adherence outcomes among randomized controlled trials. Gerontologist. 2009;49:447–62.
Iyer S, Naganathan V, McLachlan AJ, Le Couteur DG. Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging. 2008;25:1021–31.
Hering-Hanit R, Yavetz A, Dagan Y. Effect of withdrawal of misused medication on sleep disturbances in migraine sufferers with chronic daily headache. Headache. 2000;40:809–12.
Chiatti C, Bustacchini S, Furneri G, Mantovani L, Cristiani M, Misuraca C, et al. The economic burden of inappropriate drug prescribing, lack of adherence and compliance, adverse drug events in older people. Drug Saf. 2012;35:73–87.
Donovan J, Blake D, Fleming W. The patient is not a blank sheet: lay beliefs and their relevance to patient education. Rheumatology. 1989;28:58–61.
Beer C, Pk Loh, Peng YG, Potter K, Millar A. A pilot randomized controlled trial of deprescribing. Ther Adv Drug Saf. 2011;2:37–43.
Garfinkel D, Mangin D. Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy. Arch Intern Med. 2010;170:1648–54.
Williams M, Pulliam C, Hunter R, Johnson T, Owens J, Kincaid J, et al. The short-term effect of interdisciplinary medication review on function and cost in ambulatory elderly people. J Am Geriatr Soc. 2004;52:93–8.
Hilmer SN, Gnjidic D, Le Couteur DG. Thinking through the medication list-Appropriate prescribing and deprescribing in robust and frail older patients. Aust Fam Physician. 2012;41:924.
Chodosh J, Morton SC, Mojica W, Maglione M, Suttorp MJ, Hilton L, et al. Meta-analysis: chronic disease self-management programs for older adults. Ann Intern Med. 2005;143:427–38.
Nguyen GC, LaVeist TA, Harris ML, Datta LW, Bayless TM, Brant SR. Patient trust in physician and race are predictors of adherence to medical management in inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1233–9.
Lee YY, Lin JL. The effects of trust in physician on self-efficacy, adherence and diabetes outcomes. Soc Sci Med. 2009;68:1060–8.
Funding
Ms Emily Reeve’s PhD candidacy (of which this review was conducted within) is funded by an Australian Postgraduate Award (APA).
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Reeve, E., Wiese, M.D. Benefits of deprescribing on patients’ adherence to medications. Int J Clin Pharm 36, 26–29 (2014). https://doi.org/10.1007/s11096-013-9871-z
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DOI: https://doi.org/10.1007/s11096-013-9871-z