Abstract
Hyperthermophilic archaea need to adapt to their permanently hot habitats. RNA-Seq analyses were applied to obtain insights into small RNA synthesis, maturation, and stability at extreme growth temperatures. Modifications, including methylation and circularization, are used to stabilize RNA molecules. Antiviral measures are abundant in hyperthermophilic archaea which might include the frequently occurring fragmentation of tRNA genes.
Similar content being viewed by others
Literatur
Huber R, Kurr M, Jannasch HW et al. (1989) A novel group of abyssal methanogenic archaebacteria (Methanopyrus) growing at 110-degrees-C. Nature 342:833–834
Huber H, Hohn MJ, Rachel R et al. (2002) A new phylum of Archaea represented by a nanosized hyperthermophilic symbiont. Nature 417:63–67
Omer AD, Lowe TM, Russell AG et al. (2000) Homologs of small nucleolar RNAs in Archaea. Science 288:517–522
Su AA, Tripp V, Randau L (2013) RNA-Seq analyses reveal the order of tRNA processing events and the maturation of C/D box and CRISPR RNAs in the hyperthermophile Methanopyrus kandleri. Nucleic Acids Res 41:6250–6258
Randau L (2012) RNA processing in the minimal organism Nanoarchaeum equitans. Genome Biol 13:R63
Randau L, Schröder I, Söll D (2008) Life without RNase P. Nature 453:120–123
Motorin Y, Helm M (2011) RNA nucleotide methylation. Wiley Interdiscip Rev RNA 2:611–631
Starostina NG, Marshburn S, Johnson LS et al. (2004) Circular box C/D RNAs in Pyrococcus furiosus. Proc Natl Acad Sci USA 101:14097–14101
Randau L, Münch R, Hohn MJ et al. (2005) Nanoarchaeum equitans creates functional tRNAs from separate genes for their 5′- and 3′-halves. Nature 433:537–541
Randau L, Stanley BJ, Kohlway A et al. (2009) A cytidine deaminase edits C to U in transfer RNAs in Archaea. Science 324:657–659
Author information
Authors and Affiliations
Corresponding author
Additional information
Michael Daume Jahrgang 1989. 2008–2013 Biologiestudium an der Universität Marburg. Seit November 2013 Promotion am Max-Planck-Institut für terrestrische Mikrobiologie in Marburg bei Dr. L. Randau.
Lennart Randau Jahrgang 1978. 2002–2006 Promotion am Institut für Mikrobiologie, TU Braunschweig, bei Prof. Dr. D. Jahn. 2006–2010 Postdoc an der Yale University, New Haven, CT, USA (Molecular Biophysics and Biochemistry, bei Prof. Dr. D. Söll). Seit Dezember 2010 Leiter einer unabhängigen Max-Planck-Forschungsgruppe am Max-Planck-Institut für terrestrische Mikrobiologie in Marburg.
Rights and permissions
About this article
Cite this article
Daume, M., Randau, L. Thermophile archaea — RNA im Kochtopf. Biospektrum 20, 615–617 (2014). https://doi.org/10.1007/s12268-014-0494-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12268-014-0494-2