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Net Synthesis of Lecithin in an Isolated Enzyme System

Nature volume 178, pages 594–595 (1956)Cite this article

Abstract

WORK in this Laboratory1 has shown that the biosynthesis of lecithin and of phosphatidyl ethanolamine involves the intermediary formation of cytidine diphosphate choline and cytidine diphosphate ethanolamine. The enzymatic synthesis of lecithin is described in the following simplified scheme:

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References

  1. Kennedy, E. P., and Weiss, S. B., J. Amer. Chem. Soc., 77, 250 (1955). Kennedy, E. P., and Weiss, S. B., J. Biol. Chem. (in the press). Kennedy, E. P., J. Biol. Chem. (in the press).

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  2. Kennedy, E. P., J. Biol. Chem., 201, 399 (1953). Kornberg, A., and Pricer, jun., W. E., J. Biol. Chem., 204, 345 (1953). Dawson, R. M. C., Biochim. Biophys. Acta, 14, 374 (1954).

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Authors and Affiliations

  1. Ben May Laboratory for Cancer Research and Department of Biochemistry, University of Chicago, Illinois

    SAMUEL B. WEISS, SYLVIA WAGNER SMITH & EUGENE P. KENNEDY

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  1. SAMUEL B. WEISS
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  2. SYLVIA WAGNER SMITH
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  3. EUGENE P. KENNEDY
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WEISS, S., SMITH, S. & KENNEDY, E. Net Synthesis of Lecithin in an Isolated Enzyme System. Nature 178, 594–595 (1956). https://doi.org/10.1038/178594a0

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