1471-2180-7-49-4.jpg (28.27 kB)

Caspase inhibitor peptides inhibit WNV-induced PARP-cleavage

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posted on 2011-12-30, 18:29 authored by Malte C Kleinschmidt, Martin Michaelis, Henry Ogbomo, Hans-Wilhelm Doerr, Jindrich Cinatl

Copyright information:

Taken from "Inhibition of apoptosis prevents West Nile virus induced cell death"

http://www.biomedcentral.com/1471-2180/7/49

BMC Microbiology 2007;7():49-49.

Published online 29 May 2007

PMCID:PMC1891299.

Effect on WNV-induced PARP cleavage of peptides z-IETD-fmk (caspase-8 inhibitor), z-LEHD-fmk (caspase-9 inhibitor) and z-VAD-fmk (pancaspase inhibitor) at 48 h p.i. Results are expressed as percentage of values obtained from WNV-infected cultures (MOI 1) without any inhibitor added. Values represent mean (± SD) from three independent experiments. *p < 0.05 compared to untreated virus control.