1471-2105-8-386-1.jpg (31.3 kB)
Main idea of the inference framework by Markowetz
figure
posted on 2011-12-30, 19:50 authored by Holger Froehlich, Mark Fellmann, Holger Sueltmann, Annemarie Poustka, Tim BeißbarthCopyright information:
Taken from "Large scale statistical inference of signaling pathways from RNAi and microarray data"
http://www.biomedcentral.com/1471-2105/8/386
BMC Bioinformatics 2007;8():386-386.
Published online 15 Oct 2007
PMCID:PMC2241646.
: A network hypothesis is a directed graph between S-genes. Attached to each S-gene are several E-genes. Knocking down S-gene interrupts signal flow in the downstream pathway, and hence an effect of E-genes attached to and to is expected.