MGluR5 Mediates the Interaction between Late-LTP, Network Activity, and Learning
Figure 1
Prolonged mGluR5 antagonism in vivo inhibits working and reference memory performance.
A, B. MPEP was given daily (1.8 µg, i.c.v.), 30 min prior to testing of learning performance in an 8-arm radial maze where only 4 arms were baited with food. By the third trial day a significant impairment of both reference (A) and working memory (B) was apparent. Asterices denote statistical significance (p<0.05). Data are represented as mean±S.E.M.