A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
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Author
Monda, Keri L.
Chen, Gary K.
Taylor, Kira C.
Palmer, Cameron
Edwards, Todd L.
Lange, Leslie A.
Ng, Maggie C.Y.
Adeyemo, Adebowale A.
Allison, Matthew A.
Bielak, Lawrence F.
Chen, Guanji
Graff, Mariaelisa
Irvin, Marguerite R.
Rhie, Suhn K.
Li, Guo
Liu, Yongmei
Liu, Youfang
Lu, Yingchang
Nalls, Michael A.
Sun, Yan V.
Wojczynski, Mary K.
Yanek, Lisa R.
Aldrich, Melinda C.
Ademola, Adeyinka
Amos, Christopher I.
Bandera, Elisa V.
Bock, Cathryn H.
Britton, Angela
Broeckel, Ulrich
Cai, Quiyin
Caporaso, Neil E.
Carlson, Chris
Carpten, John
Casey, Graham
Chen, Wei-Min
Chen, Fang
Chen, Yii-Der I.
Chiang, Charleston W.K.
Coetzee, Gerhard A.
Demerath, Ellen
Deming-Halverson, Sandra L.
Driver, Ryan W.
Dubbert, Patricia
Feitosa, Mary F.
Freedman, Barry I.
Gillanders, Elizabeth M.
Gottesman, Omri
Guo, Xiuqing
Haritunians, Talin
Harris, Tamara
Harris, Curtis C.
Hennis, Anselm JM
Hernandez, Dena G.
McNeill, Lorna H.
Howard, Timothy D.
Howard, Barbara V.
Howard, Virginia J.
Johnson, Karen C.
Kang, Sun J.
Keating, Brendan J.
Kolb, Suzanne
Kuller, Lewis H.
Kutlar, Abdullah
Langefeld, Carl D.
Lettre, Guillaume
Lohman, Kurt
Lotay, Vaneet
Maixner, William
Meng, Yan A.
Monroe, Kristine R.
Morhason-Bello, Imran
Murphy, Adam B.
Mychaleckyj, Josyf C.
Nadukuru, Rajiv
Nathanson, Katherine L.
Nayak, Uma
N’Diaye, Amidou
Nemesure, Barbara
Wu, Suh-Yuh
Leske, M. Cristina
Neslund-Dudas, Christine
Neuhouser, Marian
Nyante, Sarah
Ochs-Balcom, Heather
Ogunniyi, Adesola
Ogundiran, Temidayo O.
Ojengbede, Oladosu
Olopade, Olufunmilayo I.
Palmer, Julie R.
Ruiz-Narvaez, Edward A.
Palmer, Nicholette D.
Press, Michael F.
Rampersaud, Evandine
Rasmussen-Torvik, Laura J.
Rodriguez-Gil, Jorge L.
Salako, Babatunde
Schadt, Eric E.
Schwartz, Ann G.
Shriner, Daniel A.
Siscovick, David
Smith, Shad B.
Wassertheil-Smoller, Sylvia
Speliotes, Elizabeth K.
Spitz, Margaret R.
Sucheston, Lara
Taylor, Herman
Tayo, Bamidele O.
Tucker, Margaret A.
Van Den Berg, David J.
Velez Edwards, Digna R.
Wang, Zhaoming
Wiencke, John K.
Winkler, Thomas W.
Witte, John S.
Wrensch, Margaret
Wu, Xifeng
Yang, James J.
Levin, Albert M.
Young, Taylor R.
Zakai, Neil A.
Cushman, Mary
Zanetti, Krista A.
Zhao, Jing Hua
Zhao, Wei
Zheng, Yonglan
Zhou, Jie
Ziegler, Regina G.
Zmuda, Joseph M.
Fernandes, Jyotika K.
Gilkeson, Gary S.
Kamen, Diane L.
Hunt, Kelly J.
Spruill, Ida J.
Ambrosone, Christine B.
Ambs, Stefan
Arnett, Donna K.
Atwood, Larry
Becker, Diane M.
Berndt, Sonja I.
Bernstein, Leslie
Blot, William J.
Borecki, Ingrid B.
Bottinger, Erwin P.
Bowden, Donald W.
Burke, Gregory
Chanock, Stephen J.
Cooper, Richard S.
Ding, Jingzhong
Duggan, David
Evans, Michele K.
Garvey, W. Timothy
Bradfield, Jonathan P.
Hakonarson, Hakon
Grant, Struan F.A.
Hsing, Ann
Chu, Lisa
Hu, Jennifer J.
Huo, Dezheng
Ingles, Sue A.
John, Esther M.
Jordan, Joanne M.
Kabagambe, Edmond K.
Kardia, Sharon L.R.
Kittles, Rick A.
Goodman, Phyllis J.
Klein, Eric A.
Kolonel, Laurence N.
Le Marchand, Loic
Liu, Simin
McKnight, Barbara
Millikan, Robert C.
Mosley, Thomas H.
Padhukasahasram, Badri
Williams, L. Keoki
Peters, Ulrike
Pettaway, Curtis A.
Peyser, Patricia A.
Psaty, Bruce M.
Rotimi, Charles N.
Rybicki, Benjamin A.
Sale, Michèle M.
Schreiner, Pamela J.
Singleton, Andrew B.
Stanford, Janet L.
Strom, Sara S.
Thun, Michael J.
Vitolins, Mara
Zheng, Wei
Moore, Jason H.
Williams, Scott M.
Zhu, Xiaofeng
Zonderman, Alan B.
Kooperberg, Charles
Papanicolaou, George
Henderson, Brian E.
Reiner, Alex P.
Loos, Ruth JF
North, Kari E.
Haiman, Christopher A.
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https://doi.org/10.1038/ng.2608Metadata
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Monda, K. L., G. K. Chen, K. C. Taylor, C. Palmer, T. L. Edwards, L. A. Lange, M. C. Ng, et al. 2013. “A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry.” Nature genetics 45 (6): 690-696. doi:10.1038/ng.2608. http://dx.doi.org/10.1038/ng.2608.Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry, and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one novel locus at 5q33 (GALNT10, rs7708584, p=3.4×10−11) and another at 7p15 when combined with data from the Giant consortium (MIR148A/NFE2L3, rs10261878, p=1.2×10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African ancestry sample (KLHL32, rs974417, p=6.9×10−8). Thirty-two of the 36 previously established BMI variants displayed directionally consistent effect estimates in our GWAS (binomial p=9.7×10−7), of which five reached genome-wide significance. These findings provide strong support for shared BMI loci across populations as well as for the utility of studying ancestrally diverse populations.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694490/pdf/Terms of Use
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