The genomic substrate for adaptive radiation in African cichlid fish
View/ Open
Author
Brawand, David
Wagner, Catherine E.
Li, Yang I.
Malinsky, Milan
Keller, Irene
Fan, Shaohua
Simakov, Oleg
Ng, Alvin Y.
Lim, Zhi Wei
Bezault, Etienne
Turner-Maier, Jason
Johnson, Jeremy
Alcazar, Rosa
Noh, Hyun Ji
Russell, Pamela
Aken, Bronwen
Alföldi, Jessica
Amemiya, Chris
Azzouzi, Naoual
Baroiller, Jean-François
Barloy-Hubler, Frederique
Berlin, Aaron
Bloomquist, Ryan
Carleton, Karen L.
Conte, Matthew A.
D'Cotta, Helena
Eshel, Orly
Gaffney, Leslie
Galibert, Francis
Gante, Hugo F.
Gnerre, Sante
Greuter, Lucie
Guyon, Richard
Haddad, Natalie S.
Haerty, Wilfried
Harris, Rayna M.
Hofmann, Hans A.
Hourlier, Thibaut
Hulata, Gideon
Jaffe, David B.
Lara, Marcia
Lee, Alison P.
MacCallum, Iain
Mwaiko, Salome
Nikaido, Masato
Nishihara, Hidenori
Ozouf-Costaz, Catherine
Penman, David J.
Przybylski, Dariusz
Rakotomanga, Michaelle
Renn, Suzy C. P.
Ribeiro, Filipe J.
Ron, Micha
Salzburger, Walter
Sanchez-Pulido, Luis
Santos, M. Emilia
Searle, Steve
Sharpe, Ted
Swofford, Ross
Tan, Frederick J.
Williams, Louise
Young, Sarah
Yin, Shuangye
Okada, Norihiro
Kocher, Thomas D.
Miska, Eric A.
Venkatesh, Byrappa
Fernald, Russell D.
Meyer, Axel
Ponting, Chris P.
Streelman, J. Todd
Lindblad-Toh, Kerstin
Seehausen, Ole
Di Palma, Federica
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/nature13726Metadata
Show full item recordCitation
Brawand, D., C. E. Wagner, Y. I. Li, M. Malinsky, I. Keller, S. Fan, O. Simakov, et al. 2014. “The genomic substrate for adaptive radiation in African cichlid fish.” Nature 513 (7518): 375-381. doi:10.1038/nature13726. http://dx.doi.org/10.1038/nature13726.Abstract
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand the molecular mechanisms underlying cichlid phenotypic diversity, we sequenced the genomes and transcriptomes of five lineages of African cichlids: the Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; and four members of the East African lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent radiation, Lake Malawi), Pundamilia nyererei (very recent radiation, Lake Victoria), and Astatotilapia burtoni (riverine species around Lake Tanganyika). We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs. In addition, we analysed sequence data from sixty individuals representing six closely related species from Lake Victoria, and show genome-wide diversifying selection on coding and regulatory variants, some of which were recruited from ancient polymorphisms. We conclude that a number of molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selection may have been important in facilitating subsequent evolutionary diversification.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353498/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351328
Collections
- HMS Scholarly Articles [17918]
Contact administrator regarding this item (to report mistakes or request changes)