Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody
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Author
Mailly, Laurent
Xiao, Fei
Lupberger, Joachim
Wilson, Garrick K.
Aubert, Philippe
Duong, François H. T.
Calabrese, Diego
Leboeuf, Céline
Fofana, Isabel
Thumann, Christine
Bandiera, Simonetta
Lütgehetmann, Marc
Volz, Tassilo
Davis, Christopher
Harris, Helen J.
Mee, Christopher J.
Girardi, Erika
Chane-Woon-Ming, Béatrice
Fletcher, Nicola
Bartenschlager, Ralf
Pessaux, Patrick
Vercauteren, Koen
Meuleman, Philip
Villa, Pascal
Kaderali, Lars
Pfeffer, Sébastien
Heim, Markus H.
Neunlist, Michel
Zeisel, Mirjam B.
Dandri, Maura
McKeating, Jane A.
Robinet, Eric
Baumert, Thomas F.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nbt.3179Metadata
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Mailly, L., F. Xiao, J. Lupberger, G. K. Wilson, P. Aubert, F. H. T. Duong, D. Calabrese, et al. 2015. “Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody.” Nature biotechnology 33 (5): 549-554. doi:10.1038/nbt.3179. http://dx.doi.org/10.1038/nbt.3179.Abstract
Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer1. Cell entry of HCV2 and other pathogens3-5 is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model6 we show that a monoclonal antibody specific for TJ protein claudin-17 eliminates chronic HCV infection without detectable toxicity. This antibody inhibits HCV entry, cell-cell transmission and virus-induced signaling events. Antibody treatment reduces the number of HCV-infected hepatocytes in vivo, highlighting the need for de novo infection via host entry factors to maintain chronic infection. In summary, we demonstrate that an antibody targeting a virus receptor can cure chronic viral infection and uncover TJ proteins as targets for antiviral therapy.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430301/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845271
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