Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts
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Tan, Lin
Wang, Hui-Fu
Tan, Meng-Shan
Tan, Chen-Chen
Zhu, Xi-Chen
Miao, Dan
Yu, Wan-Jiang
Jiang, Teng
Tan, Lan
Yu, Jin-Tai
Weiner, Michael W.
Aisen, Paul
Petersen, Ronald
Jack, Clifford R.
Jagust, William
Trojanowki, John Q.
Toga, Arthur W.
Beckett, Laurel
Saykin, Andrew J.
Morris, John
Shaw, Leslie M.
Kaye, Jeffrey
Quinn, Joseph
Silbert, Lisa
Lind, Betty
Carter, Raina
Dolen, Sara
Schneider, Lon S.
Pawluczyk, Sonia
Beccera, Mauricio
Teodoro, Liberty
Spann, Bryan M.
Brewer, James
Vanderswag, Helen
Fleisher, Adam
Heidebrink, Judith L.
Lord, Joanne L.
Mason, Sara S.
Albers, Colleen S.
Knopman, David
Johnson, Kris
Doody, Rachelle S.
Villanueva-Meyer, Javier
Chowdhury, Munir
Rountree, Susan
Dang, Mimi
Stern, Yaakov
Honig, Lawrence S.
Bell, Karen L.
Ances, Beau
Morris, John C.
Carroll, Maria
Creech, Mary L.
Franklin, Erin
Mintun, Mark A.
Schneider, Stacy
Oliver, Angela
Marson, Daniel
Griffith, Randall
Clark, David
Geldmacher, David
Brockington, John
Roberson, Erik
Love, Marissa Natelson
Grossman, Hillel
Mitsis, Effie
Shah, Raj C.
deToledo-Morrell, Leyla
Duara, Ranjan
Varon, Daniel
Greig, Maria T.
Roberts, Peggy
Albert, Marilyn
Onyike, Chiadi
D’Agostino, Daniel
Kielb, Stephanie
Galvin, James E.
Cerbone, Brittany
Michel, Christina A.
Pogorelec, Dana M.
Rusinek, Henry
de Leon, Mony J.
Glodzik, Lidia
De Santi, Susan
Doraiswamy, P. Murali
Petrella, Jeffrey R.
Borges-Neto, Salvador
Wong, Terence Z.
Coleman, Edward
Smith, Charles D.
Jicha, Greg
Hardy, Peter
Sinha, Partha
Oates, Elizabeth
Conrad, Gary
Porsteinsson, Anton P.
Goldstein, Bonnie S.
Martin, Kim
Makino, Kelly M.
Ismail, M. Saleem
Brand, Connie
Mulnard, Ruth A.
Thai, Gaby
Mc-Adams-Ortiz, Catherine
Womack, Kyle
Mathews, Dana
Quiceno, Mary
Levey, Allan I.
Lah, James J.
Cellar, Janet S.
Burns, Jeffrey M.
Swerdlow, Russell H.
Brooks, William M.
Apostolova, Liana
Tingus, Kathleen
Woo, Ellen
Silverman, Daniel H. S.
Lu, Po H.
Bartzokis, George
Graff-Radford, Neill R.
Parfitt, Francine
Kendall, Tracy
Johnson, Heather
Farlow, Martin R.
Hake, Ann Marie
Matthews, Brandy R.
Brosch, Jared R.
Herring, Scott
Hunt, Cynthia
van Dyck, Christopher H.
Carson, Richard E.
MacAvoy, Martha G.
Varma, Pradeep
Chertkow, Howard
Bergman, Howard
Hosein, Chris
Black, Sandra
Stefanovic, Bojana
Caldwell, Curtis
Hsiung, Ging-Yuek Robin
Feldman, Howard
Mudge, Benita
Assaly, Michele
Finger, Elizabeth
Pasternack, Stephen
Rachisky, Irina
Trost, Dick
Kertesz, Andrew
Bernick, Charles
Munic, Donna
Mesulam, Marek-Marsel
Lipowski, Kristine
Weintraub, Sandra
Bonakdarpour, Borna
Kerwin, Diana
Wu, Chuang-Kuo
Johnson, Nancy
Sadowsky, Carl
Villena, Teresa
Turner, Raymond Scott
Johnson, Kathleen
Reynolds, Brigid
Yesavage, Jerome
Taylor, Joy L.
Lane, Barton
Rosen, Allyson
Tinklenberg, Jared
Sabbagh, Marwan N.
Belden, Christine M.
Jacobson, Sandra A.
Sirrel, Sherye A.
Kowall, Neil
Killiany, Ronald
Budson, Andrew E.
Norbash, Alexander
Johnson, Patricia Lynn
Obisesan, Thomas O.
Wolday, Saba
Allard, Joanne
Lerner, Alan
Ogrocki, Paula
Tatsuoka, Curtis
Fatica, Parianne
Fletcher, Evan
Maillard, Pauline
Olichney, John
DeCarli, Charles
Carmichael, Owen
Kittur, Smita
Borrie, Michael
Lee, T -Y
Bartha, Rob
Johnson, Sterling
Asthana, Sanjay
Carlsson, Cynthia M.
Potkin, Steven G.
Preda, Adrian
Nguyen, Dana
Tariot, Pierre
Burke, Anna
Trncic, Nadira
Reeder, Stephanie
Bates, Vernice
Capote, Horacio
Rainka, Michelle
Scharre, Douglas W.
Kataki, Maria
Adeli, Anahita
Zimmerman, Earl A.
Celmins, Dzintra
Brown, Alice D.
Pearlson, Godfrey D.
Blank, Karen
Anderson, Karen
Flashman, Laura A.
Seltzer, Marc
Hynes, Mary L.
Santulli, Robert B.
Sink, Kaycee M.
Gordineer, Leslie
Williamson, Jeff D.
Garg, Pradeep
Watkins, Franklin
Ott, Brian R.
Querfurth, Henry
Tremont, Geoffrey
Salloway, Stephen
Malloy, Paul
Correia, Stephen
Rosen, Howard J.
Miller, Bruce L.
Perry, David
Mintzer, Jacobo
Spicer, Kenneth
Bachman, David
Pomara, Nunzio
Hernando, Raymundo
Sarrael, Antero
Relkin, Norman
Chaing, Gloria
Lin, Michael
Ravdin, Lisa
Smith, Amanda
Raj, Balebail Ashok
Fargher, Kristin
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/srep26027Metadata
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Tan, L., H. Wang, M. Tan, C. Tan, X. Zhu, D. Miao, W. Yu, et al. 2016. “Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts.” Scientific Reports 6 (1): 26027. doi:10.1038/srep26027. http://dx.doi.org/10.1038/srep26027.Abstract
The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer’s disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role of CLU in β-amyloid (Aβ) deposition, AD-related structure atrophy, abnormal glucose metabolism on neuroimaging and CSF markers to clarify the possible approach by that CLU impacts AD. Finally, four loci (rs11136000, rs1532278, rs2279590, rs7982) showed significant associations with the Aβ deposition at the baseline level while genotypes of rs9331888 (P = 0.042) increased Aβ deposition. Besides, rs9331888 was significantly associated with baseline volume of left hippocampus (P = 0.014). We then further validated the association with Aβ deposition in the AD, mild cognitive impairment (MCI), normal control (NC) sub-groups. The results in sub-groups confirmed the association between CLU genotypes and Aβ deposition further. Our findings revealed that CLU genotypes could probably modulate the cerebral the Aβ loads on imaging and volume of hippocampus. These findings raise the possibility that the biological effects of CLU may be relatively confined to neuroimaging trait and hence may offer clues to AD.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882617/pdf/Terms of Use
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