Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
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Author
McLaughlin, Russell L.
Schijven, Dick
van Rheenen, Wouter
van Eijk, Kristel R.
O'Brien, Margaret
Kahn, René S.
Ophoff, Roel A.
Goris, An
Bradley, Daniel G.
Al-Chalabi, Ammar
van den Berg, Leonard H.
Luykx, Jurjen J.
Hardiman, Orla
Veldink, Jan H.
Shatunov, Aleksey
Dekker, Annelot M.
Diekstra, Frank P.
Pulit, Sara L.
van der Spek, Rick A. A.
van Doormaal, Perry T. C.
Sproviero, William
Jones, Ashley R.
Nicholson, Garth A.
Rowe, Dominic B.
Pamphlett, Roger
Kiernan, Matthew C.
Bauer, Denis
Kahlke, Tim
Williams, Kelly
Eftimov, Filip
Fogh, Isabella
Ticozzi, Nicola
Lin, Kuang
Millecamps, Stéphanie
Salachas, François
Meininger, Vincent
de Carvalho, Mamede
Pinto, Susana
Mora, Jesus S.
Rojas-García, Ricardo
Polak, Meraida
Chandran, Siddharthan
Colville, Shuna
Swingler, Robert
Morrison, Karen E.
Shaw, Pamela J.
Hardy, John
Orrell, Richard W.
Pittman, Alan
Sidle, Katie
Fratta, Pietro
Malaspina, Andrea
Petri, Susanne
Abdulla, Susanna
Drepper, Carsten
Sendtner, Michael
Meyer, Thomas
Wiedau-Pazos, Martina
Lomen-Hoerth, Catherine
Van Deerlin, Vivianna M.
Trojanowski, John Q.
Elman, Lauren
McCluskey, Leo
Basak, Nazli
Meitinger, Thomas
Lichtner, Peter
Blagojevic-Radivojkov, Milena
Andres, Christian R.
Maurel, Cindy
Bensimon, Gilbert
Landwehrmeyer, Bernhard
Brice, Alexis
Payan, Christine A. M.
Saker-Delye, Safa
Dürr, Alexandra
Wood, Nicholas
Tittmann, Lukas
Lieb, Wolfgang
Franke, Andre
Rietschel, Marcella
Cichon, Sven
Nöuthen, Markus M.
Amouyel, Philippe
Tzourio, Christophe
Dartigues, Jean- François
Uitterlinden, Andre G.
Rivadeneira, Fernando
Estrada, Karol
Hofman, Albert
Curtis, Charles
van der Kooi, Anneke J.
de Visser, Marianne
Weber, Markus
Shaw, Christopher E.
Smith, Bradley N.
Pansarasa, Orietta
Cereda, Cristina
Del Bo, Roberto
Comi, Giacomo P.
D'Alfonso, Sandra
Bertolin, Cinzia
Sorarù, Gianni
Mazzini, Letizia
Pensato, Viviana
Gellera, Cinzia
Tiloca, Cinzia
Ratti, Antonia
Calvo, Andrea
Moglia, Cristina
Brunetti, Maura
Arcuti, Simon
Capozzo, Rosa
Zecca, Chiara
Lunetta, Christian
Penco, Silvana
Riva, Nilo
Padovani, Alessandro
Filosto, Massimiliano
Blair, Ian
Leigh, P Nigel
Casale, Federico
Chio, Adriano
Beghi, Ettore
Pupillo, Elisabetta
Tortelli, Rosanna
Logroscino, Giancarlo
Powell, John
Ludolph, Albert C.
Weishaupt, Jochen H.
Robberecht, Wim
Van Damme, Philip
Brown, Robert H.
Glass, Jonathan
Landers, John E.
Andersen, Peter M.
Corcia, Philippe
Vourc'h, Patrick
Silani, Vincenzo
van Es, Michael A.
Pasterkamp, R Jeroen
Lewis, Cathryn M.
Breen, Gerome
Corvin, Aiden
Walters, James T. R.
Farh, Kai-How
Holmans, Peter A
Bulik-Sullivan, Brendan
Collier, David A.
Agartz, Ingrid
Agerbo, Esben
Albus, Margot
Alexander, Madeline
Amin, Farooq
Bacanu, Silviu A.
Begemann, Martin
Belliveau, Richard A.
Bene, Judit
Bergen, Sarah E.
Bevilacqua, Elizabeth
Bigdeli, Tim B.
Black, Donald W.
Bruggeman, Richard
Buccola, Nancy G.
Byerley, William
Cahn, Wiepke
Cai, Guiqing
Campion, Dominique
Cantor, Rita M.
Carr, Vaughan J.
Carrera, Noa
Catts, Stanley V.
Chambert, Kimberley D.
Chan, Raymond C. K.
Chan, Ronald Y. L.
Chen, Eric Y. H.
Cheng, Wei
Cheung, Eric F. C.
Chong, Siow Ann
Cloninger, C Robert
Cohen, David
Cohen, Nadine
Cormican, Paul
Craddock, Nick
Crowley, James J.
Curtis, David
Davidson, Michael
Davis, Kenneth L.
Degenhardt, Franziska
Del Favero, Jurgen
Demontis, Ditte
Dikeos, Dimitris
Dinan, Timothy
Djurovic, Srdjan
Donohoe, Gary
Drapeau, Elodie
Duan, Jubao
Dudbridge, Frank
Durmishi, Naser
Eichhammer, Peter
Eriksson, Johan
Escott-Price, Valentina
Essioux, Laurent
Fanous, Ayman H.
Farrell, Martilias S.
Frank, Josef
Franke, Lude
Freedman, Robert
Freimer, Nelson B.
Friedl, Marion
Friedman, Joseph I.
Fromer, Menachem
Genovese, Giulio
Georgieva, Lyudmila
Giegling, Ina
Giusti-Rodríguez, Paola
Godard, Stephanie
Goldstein, Jacqueline I.
Golimbet, Vera
Gopal, Srihari
Gratten, Jacob
de Haan, Lieuwe
Hammer, Christian
Hamshere, Marian L.
Hansen, Mark
Hansen, Thomas
Haroutunian, Vahram
Hartmann, Annette M.
Henskens, Frans A.
Herms, Stefan
Hoffmann, Per
Hofman, Andrea
Hollegaard, Mads V.
Hougaard, David M.
Ikeda, Masashi
Joa, Inge
Julià, Antonio
Kalaydjieva, Luba
Karachanak-Yankova, Sena
Karjalainen, Juha
Kavanagh, David
Keller, Matthew C.
Kennedy, James L.
Khrunin, Andrey
Kim, Yunjung
Klovins, Janis
Knowles, James A.
Konte, Bettina
Kucinskas, Vaidutis
Kucinskiene, Zita Ausrele
Kuzelova-Ptackova, Hana
Kähler, Anna K.
Laurent, Claudine
Lee, Jimmy
Lee, S Hong
Legge, Sophie E.
Lerer, Bernard
Li, Miaoxin
Li, Tao
Liang, Kung-Yee
Lieberman, Jeffrey
Limborska, Svetlana
Loughland, Carmel M.
Lubinski, Jan
Lönnqvist, Jouko
Macek, Milan
Magnusson, Patrik K. E.
Maher, Brion S.
Maier, Wolfgang
Mallet, Jacques
Marsal, Sara
Mattheisen, Manuel
Mattingsdal, Morten
McDonald, Colm
McIntosh, Andrew M.
Meier, Sandra
Meijer, Carin J.
Melegh, Bela
Melle, Ingrid
Metspalu, Andres
Michie, Patricia T.
Milani, Lili
Milanova, Vihra
Mokrab, Younes
Morris, Derek W.
Mors, Ole
Murphy, Kieran C.
Murray, Robin M.
Myin-Germeys, Inez
Müller-Myhsok, Bertram
Nelis, Mari
Nenadic, Igor
Nertney, Deborah A.
Nestadt, Gerald
Nicodemus, Kristin K.
Nikitina-Zake, Liene
Nisenbaum, Laura
Nordin, Annelie
O'Callaghan, Eadbhard
O'Dushlaine, Colm
O'Neill, F Anthony
Oh, Sang-Yun
Olincy, Ann
Olsen, Line
Van Os, Jim
Pantelis, Christos
Papadimitriou, George N.
Papiol, Sergi
Parkhomenko, Elena
Pato, Michele T.
Paunio, Tiina
Pejovic-Milovancevic, Milica
Perkins, Diana O.
Pietiläinen, Olli
Pimm, Jonathan
Pocklington, Andrew J.
Pulver, Ann E.
Purcell, Shaun M.
Quested, Digby
Rasmussen, Henrik B.
Reichenberg, Abraham
Reimers, Mark A.
Richards, Alexander L.
Roussos, Panos
Ruderfer, Douglas M.
Salomaa, Veikko
Sanders, Alan R.
Schall, Ulrich
Schubert, Christian R.
Schulze, Thomas G.
Schwab, Sibylle G.
Scott, Rodney J.
Shi, Jianxin
Sigurdsson, Engilbert
Silagadze, Teimuraz
Silverman, Jeremy M.
Sim, Kang
Slominsky, Petr
So, Hon-Cheong
Spencer, Chris C. A.
Stahl, Eli A.
Stefansson, Hreinn
Steinberg, Stacy
Stogmann, Elisabeth
Straub, Richard E.
Strengman, Eric
Strohmaier, Jana
Stroup, T Scott
Subramaniam, Mythily
Suvisaari, Jaana
Svrakic, Dragan M.
Szatkiewicz, Jin P.
Söderman, Erik
Thirumalai, Srinivas
Toncheva, Draga
Tosato, Sarah
Veijola, Juha
Waddington, John
Walsh, Dermot
Wang, Dai
Wang, Qiang
Webb, Bradley T.
Weiser, Mark
Wildenauer, Dieter B.
Williams, Nigel M.
Williams, Stephanie
Witt, Stephanie H.
Wolen, Aaron R.
Wong, Emily H. M.
Wormley, Brandon K.
Xi, Hualin Simon
Zai, Clement C.
Zheng, Xuebin
Zimprich, Fritz
Wray, Naomi R.
Stefansson, Kari
Visscher, Peter M.
Adolfsson, Rolf
Andreassen, Ole A.
Blackwood, Douglas H. R.
Bramon, Elvira
Buxbaum, Joseph D.
Børglum, Anders D.
Darvasi, Ariel
Domenici, Enrico
Ehrenreich, Hannelore
Gejman, Pablo V.
Gill, Michael
Gurling, Hugh
Hultman, Christina M.
Iwata, Nakao
Jablensky, Assen V.
Jönsson, Erik G.
Kendler, Kenneth S.
Kirov, George
Knight, Jo
Lencz, Todd
Levinson, Douglas F.
Li, Qingqin S.
Liu, Jianjun
Malhotra, Anil K.
McQuillin, Andrew
Moran, Jennifer L.
Mortensen, Preben B.
Mowry, Bryan J.
Owen, Michael J.
Pato, Carlos N.
Posthuma, Danielle
Riley, Brien P.
Rujescu, Dan
Sham, Pak C.
Sklar, Pamela
St Clair, David
Weinberger, Daniel R.
Wendland, Jens R.
Werge, Thomas
Sullivan, Patrick F.
O'Donovan, Michael C.
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https://doi.org/10.1038/ncomms14774Metadata
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McLaughlin, R. L., D. Schijven, W. van Rheenen, K. R. van Eijk, M. O'Brien, R. S. Kahn, R. A. Ophoff, et al. 2017. “Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.” Nature Communications 8 (1): 14774. doi:10.1038/ncomms14774. http://dx.doi.org/10.1038/ncomms14774.Abstract
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10−4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10−7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364411/pdf/Terms of Use
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