Ultra-rare disruptive and damaging mutations influence educational attainment in the general population
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Author
Zekavat, Seyedeh M.
Kals, Mart
Nivard, Michel G.
Bloemendal, Alex
Bloom, Jonathan M.
Goldstein, Jacqueline I.
Poterba, Timothy
Seed, Cotton
Mägi, Reedik
Gage, Diane
Metspalu, Andres
Salomaa, Veikko
Suvisaari, Jaana
Purcell, Shaun M.
Sklar, Pamela
Kathiresan, Sekar
Sullivan, Patrick F.
Esko, Tõnu
Hultman, Christina
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/nn.4404Metadata
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Ganna, A., G. Genovese, D. P. Howrigan, A. Byrnes, M. Kurki, S. M. Zekavat, C. W. Whelan, et al. 2016. “Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.” Nature neuroscience 19 (12): 1563-1565. doi:10.1038/nn.4404. http://dx.doi.org/10.1038/nn.4404.Abstract
Disruptive and damaging ultra-rare variants (URVs) in highly constrained (HC) genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE; −3.1 months; P-value=3.3×10−8). This effect was stronger among high brain-expressed genes and explained more YOE variance than pathogenic copy number variation, but less than common variants. Disruptive and damaging URVs in HC genes influence the determinants of YOE in the general population.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127781/pdf/Terms of Use
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