Gene therapy insertional mutagenesis insights

Science. 2004 Jan 16;303(5656):333. doi: 10.1126/science.1091667.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • DNA-Binding Proteins / genetics*
  • Gene Expression
  • Genetic Therapy* / adverse effects
  • Genetic Vectors
  • Humans
  • LIM Domain Proteins
  • Leukemia, T-Cell / etiology
  • Leukemia, T-Cell / genetics*
  • Metalloproteins / genetics*
  • Mice
  • Mutagenesis, Insertional*
  • Proto-Oncogene Proteins
  • Receptors, Interleukin-2 / genetics*
  • Retroviridae / genetics*
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / therapy
  • Virus Integration

Substances

  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • LIM Domain Proteins
  • LMO2 protein, human
  • Lmo2 protein, mouse
  • Metalloproteins
  • Proto-Oncogene Proteins
  • Receptors, Interleukin-2