Abstract
Clinical and immunological efficiency of leukinferone in combination with polyoxidonium (immunomodulator) was studied in patients with relapsing herpetic stomatitis (RHS). The levels of alpha- and gamma-IFN were decreased, levels of IgM, IgG, and IgE were increased, active oxygen forms were actively produced, and the count of CD8(+)-cells was increased in patients with RHS. Treatment with polyoxidonium and leukinferone led to an increase of the blood levels of alpha- and gamma-IFN, decrease of IgM, IgG, and IgE levels, normalization of phagocytosis, and decrease of CD8(+)-cell count. The treatment had a pronounced clinical effect in patients with RHS of any severity, which indicates the efficiency of these drugs in combined therapy of patients with RHS.
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Adjuvants, Immunologic / therapeutic use*
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Adolescent
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Adult
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Antibody Formation / drug effects
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CD8 Antigens / blood
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Cytokines / pharmacology
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Cytokines / therapeutic use*
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Drug Combinations
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Drug Synergism
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Drug Therapy, Combination
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Female
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Humans
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Immunity, Cellular / drug effects
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Immunoglobulins / blood
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Interferon Type I / pharmacology
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Interferon Type I / therapeutic use*
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Male
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Middle Aged
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Organic Chemicals
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Phagocytosis / drug effects
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Secondary Prevention
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Stomatitis, Herpetic / blood
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Stomatitis, Herpetic / drug therapy*
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Stomatitis, Herpetic / immunology*
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Treatment Outcome
Substances
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Adjuvants, Immunologic
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CD8 Antigens
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Cytokines
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Drug Combinations
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Immunoglobulins
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Interferon Type I
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Organic Chemicals
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leukinferon
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polyoxydonium