Abstract
Bisphenol A (BPA), a synthetic chemical used in the production of plastics since the 1950s and a known endocrine disruptor, is a ubiquitous component of the material environment and human body. New research on very-low-dose exposure to BPA suggests an association with adverse health effects, including breast and prostate cancer, obesity, neurobehavioral problems, and reproductive abnormalities. These findings challenge the long-standing scientific and legal presumption of BPA's safety. The history of how BPA's safety was defined and defended provides critical insight into the questions now facing lawmakers and regulators: is BPA safe, and if not, what steps must be taken to protect the public's health? Answers to both questions involve reforms in chemical policy, with implications beyond BPA.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Air Pollutants, Occupational
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Benzhydryl Compounds
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Carcinogenicity Tests
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Dose-Response Relationship, Drug
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Endocrine Disruptors / administration & dosage
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Endocrine Disruptors / adverse effects
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Endocrine Disruptors / history
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Government Regulation
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History, 20th Century
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History, 21st Century
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Humans
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Occupational Exposure / legislation & jurisprudence*
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Occupational Health*
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Phenols / administration & dosage
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Phenols / adverse effects*
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Phenols / history
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Plastics / adverse effects*
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Plastics / history
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Politics
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United States
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United States Environmental Protection Agency
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United States Food and Drug Administration
Substances
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Air Pollutants, Occupational
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Benzhydryl Compounds
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Endocrine Disruptors
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Phenols
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Plastics
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bisphenol A