Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C

J Infect Dis. 2011 Mar 1;203(5):595-601. doi: 10.1093/infdis/jiq098. Epub 2011 Jan 21.

Abstract

Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • CD4 Lymphocyte Count
  • Case-Control Studies
  • Female
  • Genotype
  • HIV Infections / complications*
  • HIV Infections / diagnosis
  • HIV Infections / genetics
  • Hepacivirus / genetics
  • Hepatitis C / genetics*
  • Hepatitis C / virology*
  • Humans
  • Interferons
  • Interleukins / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • RNA, Viral / analysis
  • Regression Analysis
  • Treatment Outcome

Substances

  • interferon-lambda, human
  • Interleukins
  • RNA, Viral
  • Interferons