Hydroalkoxylation catalyzed by a gold(I) complex encapsulated in a supramolecular host

Z Jane Wang; Casey J Brown; Robert G Bergman; Kenneth N Raymond; F Dean Toste

doi:10.1021/ja202055v

Hydroalkoxylation catalyzed by a gold(I) complex encapsulated in a supramolecular host

J Am Chem Soc. 2011 May 18;133(19):7358-60. doi: 10.1021/ja202055v. Epub 2011 Apr 25.

Authors

Z Jane Wang¹, Casey J Brown, Robert G Bergman, Kenneth N Raymond, F Dean Toste

Affiliation

¹ Chemical Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

PMID: 21517023
DOI: 10.1021/ja202055v

Abstract

Gold(I)-phosphine complexes are readily encapsulated by a tetrahedral supramolecular host (Ga(4)L(6)). We have investigated the catalytic activity of the resulting complexes for the intramolecular hydroalkoxylation of allenes. The catalytic activity of Me(3)PAuBr was increased 8-fold by encapsulation, as determined by initial rate kinetics, and we observed up to 67 catalytic turnovers by Me(3)PAu(+) encapsulated in Ga(4)L(6).