Cyclic di-GMP, an established secondary messenger still speeding up

Environ Microbiol. 2012 Aug;14(8):1817-29. doi: 10.1111/j.1462-2920.2011.02617.x. Epub 2011 Oct 31.

Abstract

The secondary messenger cyclic di-GMP coordinately regulates the transition between motility/sessility/virulence in bacterial populations and upon adaptation to novel habitats. Thereby, multiple independent regulatory circuits regulate a diversity of targets. This specific output response is surprising considering the diverse physiological processes regulated by this signalling molecule, which range from transcription to proteolysis and clearly demonstrates the presence of sophisticated developmental programmes in these so-called simple organisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / genetics
  • Bacteria / metabolism
  • Bacteria / pathogenicity
  • Bacterial Physiological Phenomena*
  • Biofilms
  • Cyclic GMP / analogs & derivatives*
  • Cyclic GMP / metabolism
  • Cyclic GMP / physiology
  • Gene Expression Regulation, Bacterial
  • Humans
  • Second Messenger Systems / physiology*
  • Signal Transduction

Substances

  • bis(3',5')-cyclic diguanylic acid
  • Cyclic GMP