Cerebral asymmetry and language development: cause, correlate, or consequence?

Science. 2013 Jun 14;340(6138):1230531. doi: 10.1126/science.1230531.

Abstract

In most people, language is processed predominantly by the left hemisphere of the brain, but we do not know how or why. A popular view is that developmental language disorders result from a poorly lateralized brain, but until recently, evidence has been weak and indirect. Modern neuroimaging methods have made it possible to study normal and abnormal development of lateralized function in the developing brain and have confirmed links with language and literacy impairments. However, there is little evidence that weak cerebral lateralization has common genetic origins with language and literacy impairments. Our understanding of the association between atypical language lateralization and developmental disorders may benefit if we reconceptualize the nature of cerebral asymmetry to recognize its multidimensionality and consider variation in lateralization over developmental time. Contrary to popular belief, cerebral lateralization may not be a highly heritable, stable characteristic of individuals; rather, weak lateralization may be a consequence of impaired language learning.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / physiopathology*
  • Cognition Disorders / genetics
  • Cognition Disorders / physiopathology
  • Dyslexia / genetics
  • Dyslexia / physiopathology
  • Forkhead Transcription Factors / genetics
  • Functional Laterality / genetics*
  • Functional Laterality / physiology*
  • Genetic Predisposition to Disease*
  • Humans
  • Language Development
  • Language Development Disorders / genetics*
  • Language Development Disorders / physiopathology*
  • Mitochondrial Proteins
  • Nerve Tissue Proteins / genetics
  • Neuronal Plasticity / genetics
  • Neuronal Plasticity / physiology
  • Polymorphism, Single Nucleotide
  • Repressor Proteins / genetics
  • Ribosomal Proteins
  • Ultrasonography, Doppler, Transcranial / methods

Substances

  • FOXP2 protein, human
  • Forkhead Transcription Factors
  • GCFC2 protein, human
  • MRPL19 protein, human
  • Mitochondrial Proteins
  • Nerve Tissue Proteins
  • Repressor Proteins
  • Ribosomal Proteins