Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

Affiliations

• ¹ Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;
• ² Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; The Donnelly Centre, University of Toronto, Toronto, ON, Canada M5S 3E1 Canada;
• ³ Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8;
• ⁴ Department of Transformative Pathology at the Ontario Institute for Cancer Research, Ontario Institute for Cancer Research, Toronto, ON, Canada M5G 0A3;
• ⁵ Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada M5S 3G5;
• ⁶ Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada M5G 1L7;
• ⁷ Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Ontario College of Art and Design, Toronto, ON, Canada M5T 1W1;
• ⁸ Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8;
• ⁹ Department of Pathology, Queen's University, Kingston, ON, Canada K7L 3N6;
• ¹⁰ Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8; and.
• ¹¹ Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; The Donnelly Centre, University of Toronto, Toronto, ON, Canada M5S 3E1 Canada; gary.bader@utoronto.ca peter.dirks@sickkids.ca.
• ¹² Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8 gary.bader@utoronto.ca peter.dirks@sickkids.ca.