Less cholesterol means better tumor killing for cytotoxic T9 cells

Brad Griesenauer; Sophie Paczesny

doi:10.1084/jem.20180852

Less cholesterol means better tumor killing for cytotoxic T9 cells

J Exp Med. 2018 Jun 4;215(6):1505-1506. doi: 10.1084/jem.20180852. Epub 2018 May 15.

Authors

Brad Griesenauer¹, Sophie Paczesny²

Affiliations

¹ Department of Pediatrics and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
² Department of Pediatrics and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN sophpacz@iu.edu.

Abstract

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Cell Differentiation
Cholesterol
Humans
Interleukin-9*
Neoplasms*

Substances

Interleukin-9
Cholesterol