Marine Drugs (May 2011)

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

  • Tsong-Long Hwang,
  • Yang-Chang Wu,
  • Jui-Hsin Su,
  • Ching-Feng Weng,
  • Mei-Chin Lu,
  • Yung-Husan Chen,
  • Chia-Ying Tai,
  • Yin-Di Su,
  • Yu-Chia Chang,
  • Ping-Jyun Sung

DOI
https://doi.org/10.3390/md9060934
Journal volume & issue
Vol. 9, no. 6
pp. 934 – 943

Abstract

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Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.

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