@article{8622023,
  abstract     = {{The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.}},
  articleno    = {{2674}},
  author       = {{Menden, Michael P. and Wang, Dennis and Mason, Mike J. and Szalai, Bence and Bulusu, Krishna C. and Guan, Yuanfang and Yu, Thomas and Kang, Jaewoo and Jeon, Minji and Wolfinger, Russ and Nguyen, Tin and Zaslavskiy, Mikhail and Jang, In Sock and Ghazoui, Zara and Ahsen, Mehmet Eren and Vogel, Robert and Neto, Elias Chaibub and Norman, Thea and Tang, Eric K. Y. and Garnett, Mathew J. and Di Veroli, Giovanni Y. and Fawell, Stephen and Stolovitzky, Gustavo and Guinney, Justin and Dry, Jonathan R. and Saez-Rodriguez, Julio and Abante, Jordi and Abecassis, Barbara Schmitz and Aben, Nanne and Aghamirzaie, Delasa and Aittokallio, Tero and Akhtari, Farida S. and Al-lazikani, Bissan and Alam, Tanvir and Allam, Amin and Allen, Chad and de Almeida, Mariana Pelicano and Altarawy, Doaa and Alves, Vinicius and Amadoz, Alicia and Anchang, Benedict and Antolin, Albert A. and Ash, Jeremy R. and Romeo Aznar, Victoria and Ba-alawi, Wail and Bagheri, Moeen and Bajic, Vladimir and Ball, Gordon and Ballester, Pedro J. and Baptista, Delora and Bare, Christopher and Bateson, Mathilde and Bender, Andreas and Bertrand, Denis and Wijayawardena, Bhagya and Boroevich, Keith A. and Bosdriesz, Evert and Bougouffa, Salim and Bounova, Gergana and Brouwer, Thomas and Bryant, Barbara and Calaza, Manuel and Calderone, Alberto and Calza, Stefano and Capuzzi, Stephen and Carbonell-Caballero, Jose and Carlin, Daniel and Carter, Hannah and Castagnoli, Luisa and Celebi, Remzi and Cesareni, Gianni and Chang, Hyeokyoon and Chen, Guocai and Chen, Haoran and Chen, Huiyuan and Cheng, Lijun and Chernomoretz, Ariel and Chicco, Davide and Cho, Kwang-Hyun and Cho, Sunghwan and Choi, Daeseon and Choi, Jaejoon and Choi, Kwanghun and Choi, Minsoo and De Cock, Martine and Coker, Elizabeth and Cortes-Ciriano, Isidro and Cserzo, Miklos and Cubuk, Cankut and Curtis, Christina and Van Daele, Dries and Dang, Cuong C. and Dijkstra, Tjeerd and Dopazo, Joaquin and Draghici, Sorin and Drosou, Anastasios and Dumontier, Michel and Ehrhart, Friederike and Eid, Fatma-Elzahraa and ElHefnawi, Mahmoud and Elmarakeby, Haitham and van Engelen, Bo and Engin, Hatice Billur and de Esch, Iwan and Evelo, Chris and Falcao, Andre O. and Farag, Sherif and Fernandez-Lozano, Carlos and Fisch, Kathleen and Flobak, Asmund and Fornari, Chiara and Foroushani, Amir B. K. and Fotso, Donatien Chedom and Fourches, Denis and Friend, Stephen and Frigessi, Arnoldo and Gao, Feng and Gao, Xiaoting and Gerold, Jeffrey M. and Gestraud, Pierre and Ghosh, Samik and Gillberg, Jussi and Godoy-Lorite, Antonia and Godynyuk, Lizzy and Godzik, Adam and Goldenberg, Anna and Gomez-Cabrero, David and Gonen, Mehmet and de Graaf, Chris and Gray, Harry and Grechkin, Maxim and Guimera, Roger and Guney, Emre and Haibe-Kains, Benjamin and Han, Younghyun and Hase, Takeshi and He, Di and He, Liye and Heath, Lenwood S. and Hellton, Kristoffer H. and Helmer-Citterich, Manuela and Hidalgo, Marta R. and Hidru, Daniel and Hill, Steven M. and Hochreiter, Sepp and Hong, Seungpyo and Hovig, Eivind and Hsueh, Ya-Chih and Hu, Zhiyuan and Huang, Justin K. and Huang, R. Stephanie and Hunyady, Laszlo and Hwang, Jinseub and Hwang, Tae Hyun and Hwang, Woochang and Hwang, Yongdeuk and Isayev, Olexandr and Walk, Oliver Bear Don't and Jack, John and Jahandideh, Samad and Ji, Jiadong and Jo, Yousang and Kamola, Piotr J. and Kanev, Georgi K. and Karacosta, Loukia and Karimi, Mostafa and Kaski, Samuel and Kazanov, Marat and Khamis, Abdullah M. and Khan, Suleiman Ali and Kiani, Narsis A. and Kim, Allen and Kim, Jinhan and Kim, Juntae and Kim, Kiseong and Kim, Kyung and Kim, Sunkyu and Kim, Yongsoo and Kim, Yunseong and Kirk, Paul D. W. and Kitano, Hiroaki and Klambauer, Gunter and Knowles, David and Ko, Melissa and Kohn-Luque, Alvaro and Kooistra, Albert J. and Kuenemann, Melaine A. and Kuiper, Martin and Kurz, Christoph and Kwon, Mijin and van Laarhoven, Twan and Laegreid, Astrid and Lederer, Simone and Lee, Heewon and Lee, Jeon and Lee, Yun Woo and Leppaho, Eemeli and Lewis, Richard and Li, Jing and Li, Lang and Liley, James and Lim, Weng Khong and Lin, Chieh and Liu, Yiyi and Lopez, Yosvany and Low, Joshua and Lysenko, Artem and Machado, Daniel and Madhukar, Neel and De Maeyer, Dries and Malpartida, Ana Belen and Mamitsuka, Hiroshi and Marabita, Francesco and Marchal, Kathleen and Marttinen, Pekka and Mason, Daniel and Mazaheri, Alireza and Mehmood, Arfa and Mehreen, Ali and Michaut, Magali and Miller, Ryan A. and Mitsopoulos, Costas and Modos, Dezso and Van Moerbeke, Marijke and Moo, Keagan and Motsinger-Reif, Alison and Movva, Rajiv and Muraru, Sebastian and Muratov, Eugene and Mushthofa, Mushthofa and Nagarajan, Niranjan and Nakken, Sigve and Nath, Aritro and Neuvial, Pierre and Newton, Richard and Ning, Zheng and De Niz, Carlos and Oliva, Baldo and Olsen, Catharina and Palmeri, Antonio and Panesar, Bhawan and Papadopoulos, Stavros and Park, Jaesub and Park, Seonyeong and Park, Sungjoon and Pawitan, Yudi and Peluso, Daniele and Pendyala, Sriram and Peng, Jian and Perfetto, Livia and Pirro, Stefano and Plevritis, Sylvia and Politi, Regina and Poon, Hoifung and Porta, Eduard and Prellner, Isak and Preuer, Kristina and Angel Pujana, Miguel and Ramnarine, Ricardo and Reid, John E. and Reyal, Fabien and Richardson, Sylvia and Ricketts, Camir and Rieswijk, Linda and Rocha, Miguel and Rodriguez-Gonzalvez, Carmen and Roell, Kyle and Rotroff, Daniel and de Ruiter, Julian R. and Rukawa, Ploy and Sadacca, Benjamin and Safikhani, Zhaleh and Safitri, Fita and Sales-Pardo, Marta and Sauer, Sebastian and Schlichting, Moritz and Seoane, Jose A. and Serra, Jordi and Shang, Ming-Mei and Sharma, Alok and Sharma, Hari and Shen, Yang and Shiga, Motoki and Shin, Moonshik and Shkedy, Ziv and Shopsowitz, Kevin and Sinai, Sam and Skola, Dylan and Smirnov, Petr and Soerensen, Izel Fourie and Soerensen, Peter and Song, Je-Hoon and Song, Sang Ok and Soufan, Othman and Spitzmueller, Andreas and Steipe, Boris and Suphavilai, Chayaporn and Tamayo, Sergio Pulido and Tamborero, David and Tang, Jing and Tanoli, Zia-ur-Rehman and Tarres-Deulofeu, Marc and Tegner, Jesper and Thommesen, Liv and Tonekaboni, Seyed Ali Madani and Tran, Hong and De Troyer, Ewoud and Truong, Amy and Tsunoda, Tatsuhiko and Turu, Gabor and Tzeng, Guang-Yo and Verbeke, Lieven and Videla, Santiago and Vis, Daniel and Voronkov, Andrey and Votis, Konstantinos and Wang, Ashley and Wang, Hong-Qiang Horace and Wang, Po-Wei and Wang, Sheng and Wang, Wei and Wang, Xiaochen and Wang, Xin and Wennerberg, Krister and Wernisch, Lorenz and Wessels, Lodewyk and van Westen, Gerard J. P. and Westerman, Bart A. and White, Simon Richard and Willighagen, Egon and Wurdinger, Tom and Xie, Lei and Xie, Shuilian and Xu, Hua and Yadav, Bhagwan and Yau, Christopher and Yeerna, Huwate and Yin, Jia Wei and Yu, Michael and Yu, MinHwan and Yun, So Jeong and Zakharov, Alexey and Zamichos, Alexandros and Zanin, Massimiliano and Zeng, Li and Zenil, Hector and Zhang, Frederick and Zhang, Pengyue and Zhang, Wei and Zhao, Hongyu and Zhao, Lan and Zheng, Wenjin and Zoufir, Azedine and Zucknick, Manuela}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{ANDROGEN RECEPTOR,BREAST-CANCER,GENE,CELL,INHIBITION,RESISTANCE,PATHWAY,MUTATIONS,LANDSCAPE,RESOURCE}},
  language     = {{eng}},
  pages        = {{17}},
  publisher    = {{Nature Publishing Group}},
  title        = {{Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen}},
  url          = {{http://doi.org/10.1038/s41467-019-09799-2}},
  volume       = {{10}},
  year         = {{2019}},
}

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