Terpenoids from the Octocoral Sinularia gaweli

Wun-Jie Lin; Tung-Ying Wu; Tzu-Rong Su; Zhi-Hong Wen; Jih-Jung Chen; Lee-Shing Fang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/ijms160819508

International Journal of Molecular Sciences (Aug 2015)

Terpenoids from the Octocoral Sinularia gaweli

Wun-Jie Lin,
Tung-Ying Wu,
Tzu-Rong Su,
Zhi-Hong Wen,
Jih-Jung Chen,
Lee-Shing Fang,
Yang-Chang Wu,
Ping-Jyun Sung

Affiliations

Wun-Jie Lin: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
Tung-Ying Wu: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Tzu-Rong Su: Department of Beauty Science, Meiho University, Pingtung 912, Taiwan
Zhi-Hong Wen: Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Jih-Jung Chen: Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Lee-Shing Fang: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Yang-Chang Wu: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Ping-Jyun Sung: Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan

DOI: https://doi.org/10.3390/ijms160819508
Journal volume & issue: Vol. 16, no. 8
pp. 19508 – 19517

Abstract

Read online

Two eudesmane sesquiterpenoids, verticillatol (1) and 5α-acetoxy-4(14)-eudesmene-1β-ol (2) and two cembrane diterpenoids, (–)-leptodiol acetate (3) and sinulacembranolide A (4) were isolated from the octocoral Sinularia gaweli and compounds 2–4 are new isolates. The structures of new terpenoids 2–4 were elucidated by spectroscopic methods and by comparison the spectral data with those of known analogues. Terpenoid 4 was found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 marcophage cells.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

About the journal

Abstract

Keywords