Molecules (Jul 2012)
Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-<em>c</em>][1,4]benzodiazepine (PBDT) Derivatives
Abstract
A series of amido-substituted triazolopyrrolo[2,1-<em>c</em>][1,4]benzodiazepine (<strong>PBDT</strong>) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound <strong>PBDT-7i</strong> with the <em>meta</em>-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
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