Molecules (Jul 2012)

Synthesis and Cytotoxicity Testing of New Amido-Substituted Triazolopyrrolo[2,1-<em>c</em>][1,4]benzodiazepine (PBDT) Derivatives

  • Bo-Ying Bao,
  • Chia-Hao Su,
  • Min-Chiau Laiu,
  • Khagga Mukkanti,
  • Srinivas Pusuluri,
  • Chi-Fen Chang,
  • Kumaraswamy Sorra,
  • Ta-Hsien Chuang

DOI
https://doi.org/10.3390/molecules17088762
Journal volume & issue
Vol. 17, no. 8
pp. 8762 – 8772

Abstract

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A series of amido-substituted triazolopyrrolo[2,1-<em>c</em>][1,4]benzodiazepine (<strong>PBDT</strong>) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound <strong>PBDT-7i</strong> with the <em>meta</em>-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.

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