Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

Chi-Fen Chang; Yu-Lin Hsu; Chao-Ying Lee; Chia-Hua Wu; Yang-Chang Wu; Ta-Hsien Chuang

doi:10.3390/ijms16023980

International Journal of Molecular Sciences (Feb 2015)

Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

Chi-Fen Chang,
Yu-Lin Hsu,
Chao-Ying Lee,
Chia-Hua Wu,
Yang-Chang Wu,
Ta-Hsien Chuang

Affiliations

Chi-Fen Chang: Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan
Yu-Lin Hsu: Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan
Chao-Ying Lee: School of Pharmacy, China Medical University, Taichung 40402, Taiwan
Chia-Hua Wu: School of Pharmacy, China Medical University, Taichung 40402, Taiwan
Yang-Chang Wu: School of Pharmacy, China Medical University, Taichung 40402, Taiwan
Ta-Hsien Chuang: School of Pharmacy, China Medical University, Taichung 40402, Taiwan

DOI: https://doi.org/10.3390/ijms16023980
Journal volume & issue: Vol. 16, no. 2
pp. 3980 – 3989

Abstract

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Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl) phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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