Origins of the cytolytic synapse.
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Peer-reviewed
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Abstract
Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell, and marked reorganization of both the actin and the microtubule cytoskeletons brings the centrosome up to the plasma membrane to the point of T cell receptor signalling. Secretory granules move towards the centrosome and are delivered to this focal point of secretion. Such centrosomal docking at the plasma membrane also occurs during ciliogenesis; indeed, striking similarities exist between the cytolytic synapse and the primary cilium that throw light on the possible origins of immune synapses.
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Keywords
Animals, Cytotoxicity, Immunologic, Humans, Immunological Synapses, T-Lymphocytes, Cytotoxic
Journal Title
Nat Rev Immunol
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Journal ISSN
1474-1733
1474-1741
1474-1741
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Springer Science and Business Media LLC
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Sponsorship
Wellcome Trust (107609/Z/15/Z)
Cancer Research UK (C14303/A17197)
Wellcome Trust (103930/Z/14/Z)
Cancer Research UK (C14303/A17197)
Wellcome Trust (103930/Z/14/Z)
GMG is funded by Wellcome Trust Principal Research Fellowship [103930], MDR is now funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society [107609].