Pediatrics: Basic Research
Moderated Poster 11: Sunday, May 15, 2011: 10:30 AM-12:30 PM
252 HYPOSPADIAS ON THE RISE IN ARKANSAS: EPIDEMIOLOGIC ASSESSMENT

https://doi.org/10.1016/j.juro.2011.02.343Get rights and content

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INTRODUCTION AND OBJECTIVES

Hypospadias is one of the most common congenital malformations, but causative factors are poorly defined. We assessed the prevalence of hypospadias in Arkansas in order to explore temporal, demographic, and geographical differences using data from a population-based active surveillance system.

METHODS

Ascertainment was performed among 1506 male births from women residing in Arkansas from 1998–2007 with 51 cases excluded due to inability to confirm Arkansas birth, duplication of records, and stillbirth. Select maternal and infant characteristics determined from surveillance data were categorized into subgroups. Prevalence for each sub-group was calculated among all births and was based on the prevalence for each sub-group reported per 10,000 births (95% confidence intervals computed using

RESULTS

1,455/196,142 males were identified to have hypospadias with a significantly higher prevalence rate (75.0) than other states with comparable birth defect surveillance programs (range 37.9–62.2). Degrees of hypospadias were graded as 1st (coronal-distal) in 60.7% of cases, 2nd (mid penile-subcoronal) in 18.8%, 3rd (perineal-proximal penile) in 4.6%, and hypospadias NOS (not otherwise specified) in 16%. The prevalence of hypospadias increased during the surveillance period: 66.9 (1998–02) vs 81.0

CONCLUSIONS

Hypospadias prevalence in Arkansas is on the rise and is significantly higher than other states in the surveillance group. In light of these factors and the existing buccal tissue repository, there is an opportunity for genetic probing to identify causative factors for hypospadias. Improvement in the categorization of degrees of hypospadias also may have an impact on the reported prevalence rates.

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