Imaging/Radiology: UroradiologyModerated Poster 74: Wednesday, May 18, 2011: 3:30 PM-5:30 PM2309 IMPACT OF CLINICAL PARAMETERS ON THE DIAGNOSTIC ACCURACY OF ENDORECTAL COIL MAGNETIC RESONANCE IMAGING FOR THE DETECTION OF PROSTATE CANCER
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INTRODUCTION AND OBJECTIVES
For preoperative assessment, endorectal coil magnetic resonance imaging (endoMRI) of the prostate is a useful tool to evaluate tumor localization, size and topographic relation to the neurovascular bundles. However, there is little evidence of patient characteristics affecting its diagnostic performance. The aim of this study was to evaluate the influence of clinical and histological parameters on the accuracy of endoMRI in prostate cancer patients.
METHODS
69 consecutive patients with histologically proven prostate cancer were included into the study. After virtually dividing the prostate into pixels of one cm2 results of endoMRI were compared to the corresponding results from prostatectomy specimens' whole mount sections by pixel. Univariate and multivariate analyses were performed to calculate the impact of clinical and histological parameters on the number of appropriately described pixels.
RESULTS
In 9 patients no tumor could be demonstrated by endoMRI. 48.3% of the remaining patients were staged correctly, 23.3% were over- and 28.3% under staged. Overall, mean rate of correctly labelled pixels were 0.44 (±SEM 0.04) for tumor and 0.90 (±0.01) for benign segments. In univariate analysis the rate of correctly labelled tumor segments showed significant positive correlations to Gleason Score ≥7 and negative correlations to prostate weight and multifocularity. The rate of correctly labelled
CONCLUSIONS
Our data suggest that the reliability of endoMRI depends on clinical parameters. It is increasing with higher Gleason Scores, in case of unifocal tumors and in smaller prostate glands. These findings should be taken into account when interpreting endoMRI findings before decision-making regarding any type of local therapy.
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