Endogenous Neuromodulation at Infralow Frequencies
Section snippets
The Clinical Method
The clinical approach is based entirely on inviting the brain to engage with information derived from the low-frequency EEG. Typically the signal is presented in the form of a video display, often accompanied by tactile feedback. A bipolar montage is used exclusively. This informs the brain as to the time course of the differential activation at two cortical sites.36 It also serves the usual purpose of suppressing common-mode signals, such as nonneuronal influences on the signal.37 The spectral
The Hierarchy of Regulation
If the brain is regarded as a control system, its fundamental responsibility is to assure its own unconditional stability.38, 39 This is a particular challenge because to function in a real-time environment, the brain is also constrained to work in a critical state, poised for rapid, macroscopic state change.40, 41 This maintains the brain far from an equilibrium state. This implies a narrow parameter space for both optimum responsiveness and stability in the vulnerable brain. Ultimately we
The Protocols in the Spatial Domain
Protocol development has proceeded largely empirically, informed at all times by considerations of functional neuroanatomy. The critical drivers in this development were instability and severe dysregulation. A broad generalization has been consolidated over the years that brain stability is best promoted with interhemispheric placements.49, 50 The placement offering the strongest effects and greatest breadth of clinical effect is T3-T4. The most severe cases of dysregulation observed in
The Protocols in the Frequency Domain
The unstable brain is the most sensitive to the parameters of the training, in particular, the target frequency. Because of the extreme sensitivity to target frequency, the right-hemisphere issues drove the agenda for the deepening penetration of the ILF region. The most difficult and intractable cases tended to require the lowest target frequencies. Whereas the initial thrust into the lowest frequency region was mandated by our most challenging clients, by now it is clear that nearly everyone
Assessment
Assessment covers a broad range of observables that can capture the quality of system functioning and characterize the nature of the particular dysregulation at issue. Client history is extensively explored, with emphasis on early developmental issues. Brain stability and arousal regulation are probed with a continuous performance test (CPT) with everyone capable of taking the test. The expectation for successful training is that the CPT measures normalize or at least improve. The test tracks
Discrimination of the Slow Cortical Potential
It has been convenient to describe the brain’s engagement with its own EEG in anthropomorphic terms. It is necessary to demonstrate, however, that translation of the simplistic model into a viable neurophysiological model is in prospect. An analogy may be helpful. The driver on a Los Angeles freeway is likely to have turned over the job of steering the car to his brain while his mind is engaged on higher matters. And even if his mind were to turn to thoughts of suicide, the brain would still
Feedback on Spectral Properties of the EEG
The roots of frequency-based neurofeedback go back to animal research performed in the 1960s. In the course of sleep research on cats, a bursting rhythm was identified in sensorimotor cortex while the cats were motorically idle.10 Termed the sensorimotor rhythm (SMR), the spindle bursts occurred at the same frequency as the sleep spindle and thus were identified with it. Operant conditioning to promote the appearance of SMR bursts altered both the waking and sleep behavior of the cats.63, 64
Disorders of Sleep Regulation
As the quality of sleep is a good index to the quality of arousal regulation, it is an appropriate starting point for a discussion of clinical effects.85 Remediation of insomnia was originally reported for SMR training for cases involving an anxiety condition.74 ILF training has been found to be more generally helpful with ordinary insomnia—delayed sleep onset, frequent waking, failure to return to sleep after early wakening, etc. The effects are often felt after a single session. Given the
An Appraisal and a Projection
Understanding and treating the brain in the perspective of its functioning as a dynamically regulated, hierarchical control system has turned out to be highly fruitful, and portends significant implications for clinical neurology and psychiatry, and for all the neurosciences. Stimulating and promoting endogenous mechanisms of recovery allows for a level of subtlety, refinement, and comprehensiveness in clinical practice that is not available with existing exogenous therapies.
The potential is
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Endogenous neuromodulation at infra-low frequencies
2023, Introduction to Quantitative EEG and Neurofeedback: Third EditionMilestones in development of the othmer method
2019, Neurofeedback: The First Fifty YearsToward a Frequency-based Theory of Neurofeedback
2017, Rhythmic Stimulation Procedures in NeuromodulationInfralow neurofeedback in the treatment of substance use disorders: a randomized controlled trial
2022, Journal of Psychiatry and NeuroscienceInfra-low frequency neurofeedback and insomnia as a model of CNS dysregulation
2022, Frontiers in Human Neuroscience
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