Anti-cancer effect of kaffir lime (Citrus Hystrix DC) leaf extract in cervical cancer and neuroblastoma cell lines
- Previous study showed that kaffir lime leaf contains alkaloid, flavonoid, terpenoid, tannin and saponin. The objective of this study was to examine the cytotoxic effect of kaffir lime leaf extract on cervical cancer and neuroblastoma cell lines. The method used for this research to determine cell viability was an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results showed that an ethyl acetate extract had an IC50 for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental cells of 40.7 μg · mL–1, 28.4 μg · mL–1, 14.1 μg · mL–1, and 25.2 μg · mL–1 respectively. Furthermore, the IC50 of chloroform extracts for HeLa cells, UKF-NB3, IMR-5 and SK-N-AS parental were 17.6 μg · mL–1, 18.9 μg · mL–1, 6.4 μg · mL–1, and 9.4 μg · mL–1 respectively. These data showed that kaffir lime extract reduces the viability of cervical and neuroblastoma cell lines and may have potential as anti-cancer compounds.
Download full text files
Additional Services
| Author: | Woro Anindito Sri TunjungORCiD, Jindrich CinatlORCiDGND, Martin MichaelisORCiDGND, Christopher Mark SmalesORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-759517 |
| DOI: | https://doi.org/https://doi.org/10.1016/j.proche.2015.03.062 |
| ISSN: | 1876-6196 |
| Parent Title (English): | Procedia Chemistry |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u.a.] |
| Document Type: | Conference Proceeding |
| Language: | English |
| Year of Completion: | 2015 |
| Year of first Publication: | 2015 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Contributing Corporation: | 2nd Humboldt Kolleg in conjunction with International Conference on Natural Sciences, HK-ICONS 2014 |
| Release Date: | 2023/09/19 |
| Tag: | MTT assay; cervical cancer; kaffir lime; neuroblastoma |
| Volume: | 14 |
| Page Number: | 4 |
| First Page: | 465 |
| Last Page: | 468 |
| HeBIS-PPN: | 512122563 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
