UID:
almahu_9948026328902882
Format:
1 online resource (567 p.)
Edition:
2nd ed.
ISBN:
1-281-05816-5
,
9786611058166
,
0-08-053814-2
Series Statement:
Studies in organic chemistry ; 51
Content:
The first edition of this book was welcomed with great enthusiasm by teachers and students. It therefore seemed opportune to publish a second, revised, updated and extended edition. Unfortunately, Professor Fèlix Serratosa died before he could complete this task. Some new material has been added, the more significant changes being: 1) The book has been restructured into two well-differentiated sections: Part A, dealing with conventional organic synthesis, and Part B, devoted exclusively to computer-assisted organic synthesis and based on the former Chapter 11 and Appendices 2, 3 and
Note:
Includes index.
,
Front Cover; Organic Chemistry in Action: The Design of Organic Synthesis; Copyright Page; CONTENTS; PART A: THE DESIGN OF ORGANIC SYNTHESIS; CHAPTER 1. HEURISTICS AND ORGANIC SYNTHESIS. PURE SUBSTANCES; 1.1. The chemical and the philosophical concept of ""synthesis"": from Aristotle to Kant; 1.2. Organic synthesis as a heuristic activity; 1.3. Pure substances. Language: The Classical Structural Theory; 1.4. The objectives of organic synthesis; 1.5. New times, new targets; 1.6. Synthesis as a sequence of unequivocal steps. Economy: conversion, selectivity and yield. Starting materials
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1.7. Carbon skeleton, functional group manipulation and stereochemical control. Rule of maximum simplicity1.8. Molecular complexity and synthetic analysis; REFERENCES; Appendix A-1 GRAPH THEORY. MOLECULAR COMPLEXITY INDICES; REFERENCES; CHAPTER 2. THE REACTIVITY OF ORGANIC MOLECULES; 2.1. Some general remarks on the reactivity of organic compounds; 2.2. Molecules as ionic aggregates. The Lapworth-Evans model; 2.3. Classification of functional groups according to D. A. Evans; 2.4. Consonant and dissonant bifunctional relationships; REFERENCES; CHAPTER 3. METHODOLOGIES. SYNTHESIS TREE
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3.1. The retrosynthetic process. Methodologies for the design of organic synthesis. The synthesis tree3.2. Biogenetic considerations. Biomimetic synthesis; 3.3. Mass Spectra and the Retro-Mass Spectral synthesis; 3.4. The mathematical model of constitutional chemistry. The programs EROS and IGOR; 3.5. Structural synthetic analysis, simplification and generation of the intermediate precursors of the ""synthesis tree"". Principle of microscopic reversibility; 3.6. Auxiliary. physical techniques in the synthesis of organic compounds; REFERENCES
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CHAPTER 4. SYNTHETIC STRUCTURAL ANALYSIS. SIMPLIFICATION. HETEROLYTIC DISCONNECTIONS: HEURISTIC PRINCIPLES4.1. Symmetry; 4.2. Functional groups; 4.3. The carbon skeleton: chains, rings and appendages; REFERENCES; CHAPTER 5. SYNTHESIS OF DISSONANT SYSTEMS; 5.1. Illogical disconnections: reactivity inversion; 5.2. Plausible disconnections: dissonant three-membered rings; 5.3. Sigmatropic rearrangements; 5.4. Reconnection of bifunctional dissonant systems to rings; 5.5. Homolytic disconnections: couplings involving electron-transfer; REFERENCES; CHAPTER 6. MONOCYCLIC AND POLYCYCLIC SYSTEMS
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6.1. Retro-annulations6.2. Cycloreversions: pericyclic and cheletropic disconnections. The Woodward-Hoffmann rules; 6.3. Heterocyclic compounds; REFERENCES; CHAPTER 7. SYSTEMS WITH UNUSUAL STRUCTURAL FEATURES: QUATERNARY CARBON ATOMS, MEDIUM-SIZED RINGS AND BRIDGED SYSTEMS...; 7.1. Rearrangements and internal fragmentations; 7.2. Bridged systems; REFERENCES; CHAPTER 8. STEREOCHEMICAL CONTROL IN MONOCYCLIC AND POLYCYCLIC SYSTEMS; 8.1. Introduction; 8.2. Specificity, selectivity, order and negative entropy; 8.3. Diastereoselectivity in monocyclic and polycyclic systems; REFERENCES
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CHAPTER 9. ACYCLIC STEREOSELECTION. I: STEREOCONTROLLED ALDOL CONDENSATION
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English
Additional Edition:
ISBN 0-444-81935-5
Language:
English
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