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Berlin Brandenburg

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  • 1
    In: Physical Chemistry Chemical Physics, 1999, Vol.1(20), pp.4833-4841
    Description: The conformational behaviour of phosphatidylcholine and phosphatidyl acid membranes derived from octadec-14-ynoic and octadec-9-ynoic acid is studied by FTIR spectroscopy comprising both the liquid crystalline and gel phases. In the vicinity of the transition from the gel to the liquid crystalline phase the conformational changes of the acyl chains are followed by the analysis of the CH 2 stretching bands and CH 2 wagging band progressions. In the liquid crystalline phase a quantitative determination of the amounts of gauche - trans - gauche , double gauche , and end gauche conformers is achieved by the analysis of the CH 2 wagging band region. In this connection, several model compounds (hex-2-yne, and hex-3-yne, oct-4-yne) have been examined to assist the assignment of a special vibration band at 1328 cm -1 due to the CH 2 –C 3 C unit. The results for the phospholipids studied here clearly demonstrate that the conformational properties critically depend on their actual lipid structure, sample composition and sample temperature. The derived data are discussed in conjunction with earlier investigations of more “conventional’' lipid systems—mainly containing saturated acyl chains—to evaluate the specific influence of the incorporation of the C–C triple bond into the fatty acid chains.
    ISSN: 1463-9076
    E-ISSN: 1463-9084
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  • 2
    Language: English
    In: Nuclear Instruments and Methods in Physics Research, A, March 11, 2013, Vol.704, p.7(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.nima.2012.11.095 Byline: Hartmut Buttig, A. Arnold, A. Buchner, M. Justus, M. Kuntsch, U. Lehnert, P. Michel, R. Schurig, G. Staats, J. Teichert Keywords: Solid state RF power amplifiers; Superconducting CW RF; 1.3GHz solid state RF-power amplifiers; ELBE-RF; Superconducting LINAC RF Abstract: The RF power for the superconducting 1.3GHz CW LINAC "ELBE" has been doubled from less than 10kW to 20kW per cavity. In January 2012 the four 10kW klystrons used to drive the four superconducting cavities of the LINAC have been replaced by pairs of 10kW solid state power amplifiers (SSPA). ELBE is now worldwide the first 1.3GHz CW LINAC equipped with solid state RF power amplifiers. This technical note details on this project. Author Affiliation: Radiation Source ELBE, Helmholtz Zentrum Dresden-Rossendorf, Germany Article History: Received 11 June 2012; Revised 19 November 2012; Accepted 20 November 2012
    Keywords: Power Amplifiers ; Nuclear Radiation ; Superconductors
    ISSN: 0168-9002
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Oncotarget, 13 April 2018, Vol.9(28), pp.19613-19622
    Description: While various studies characterized clinical and prognostic properties of diffuse large B-Cell lymphoma (DLBCL) and transformed indolent lymphomas, the clinicopathological features of indolent lymphoma and simultaneous secondary transformation upon initial diagnosis (ssDLBCL) are insufficiently established. Between 2010 and 2017, 247 consecutive patients admitted to our institution and treated for DLBCL were investigated for composite histology of ssDLBCL-type. Upon systematical histopathological evaluation composite histology was identified in 22/247 cases (8.9%). The predominant histology of the underlying indolent lymphoma was follicular lymphoma of variable grading (I-IIIA; 81.8%) whereas marginal zone lymphoma represented a minor sub group (18.2%). Clinicopathological investigation revealed a high degree of concordance between ssDLBCL and DLBCL upon initial diagnosis and clinical courses were shown to be strikingly similar. The predominant fraction of ssDLBCL were germinal center derived lymphomas (GCB-type) with a trend towards a superior outcome compared with non-GCB-type ssDLBCL. Additionally, we demonstrate a significant adverse prognostic impact of an underlying indolent lymphoma component other than follicular-type lymphoma (e.g. marginal zone lymphoma). Moreover, the frequency of double-hit (DHL) or double-expressor lymphomas (DEL) appears to be low. Our findings provide substantial insight into the behavior of ssDLBCL, highlight the ramifications of the concurrent high-grade fraction within indolent lymphomas and underline therapeutic efficacy of R-CHOP type immunochemotherapy in the majority of ssDLBCL patients.
    Keywords: Cell-of-Origin ; Composite Histology ; de Novo Diffuse Large B-Cell Lymphoma ; Prognosis ; Transformed Indolent Lymphoma
    E-ISSN: 1949-2553
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  • 4
    Language: English
    In: Journal of Cancer Research and Clinical Oncology, 2019, Vol.145(1), pp.129-136
    Description: Purpose The introduction of immunochemotherapy has led to a significant improvement in treatment results and prognosis of diffuse large B-cell non-Hodgkins lymphoma (DLBCL) both at initial diagnosis and in relapse. Trofosfamide, an oxazaphosphorine derivative, has been utilized as alternative treatment option for patients with lymphoproliferative diseases unsuitable for conventional chemotherapy agents and protocols because of age, comorbidity, or poor performance score. While data on the activity and safety of single-agent trofosfamide have been published, the potential value of this agent in immunochemotherapy in combination with anti-CD20 antibodies such as rituximab has not been investigated to our knowledge. Methods Safety and therapeutic effectiveness of trofosfamide given orally at a dose of 50 mg twice daily alone, or in combination with standard-dose rituximab, was investigated in a cohort of elderly and/or highly comorbid patients with histologically confirmed primary or secondary DLBCL. Results Treatment with trofosfamide in this combination setting was generally well tolerated with no treatment-related deaths and manageable side effects, most of which were WHO class I–II; the most clinically relevant toxicity was cytopenia. 19 of 21 examined patients responded to therapy with 11 of 21 (52.4%) achieving a complete remission (CR). Median overall and progression-free survival (OS and PFS) in the CR-group was 14 and 9 months, respectively. In the subgroup with trofosfamide-based first-line therapy, 7 of 10 (70%) achieved CR and median PFS was not reached. Conclusions Immunochemotherapy with rituximab and trofosfamide (RT) is safe and effective in elderly and poor-performance patients with DLBCL. Response rates are comparable to most commonly used primary and salvage treatment protocols. The potential value of TR regimen in both first-line and relapsed/refractory DLCBL merits further investigation and is probably underestimated.
    Keywords: Trofosfamide ; Diffuse large B-cell lymphoma ; Elderly ; Prognosis
    ISSN: 0171-5216
    E-ISSN: 1432-1335
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  • 5
    Language: English
    In: Anticancer research, October 2014, Vol.34(10), pp.5503-7
    Description: Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) frequently observed in young patients. High-dose immunochemotherapy constitutes the current therapeutic gold-standard, despite significant toxicity and serious late effects. Several hotspots harboring oncogenic gain-of-function mutations were recently shown to pose vital hallmarks in activated B-cell like (ABC-) (CD79B, CARD11 and MYD88) and germinal center like (GCB-) DLBCL (EZH2), respectively. Several promising targeted-therapy approaches, derived from these findings, are currently under development. We thoroughly characterized a cohort of 25 untreated patients with de novo PMBL by immunohistochemical and cytogenetic means and assessed the prevalence of activating mutations affecting EZH2, CD79B and CARD11 utilizing a polymerase chain reaction (PCR)-based capillary sequencing approach. Moreover, the MYD88 p. L265P status was assessed by employing a pyrosequencing approach. PMBLs included in this study did not harbor any of the reported hotspot mutations activating the nuclear factor (NF)-kappa B signaling cascade or the EZH2-mediated epigenetic deregulation of gene expression. Immunohistochemical characterization revealed an ABC phenotype in 44% (n=11) of cases. We report that genetic alterations of these genes are rare events in PMBL unlike other subtypes of DLBCL. Our findings suggest that a substantial subset of PMBL patients may benefit from treatment approaches targeting BCR-mediated activation of NF-kappa B.
    Keywords: Card11 ; Cd79b ; Ezh2 ; Myd88 ; Nfkappab Pathway ; Primary Mediastinal Large B-Cell Lymphoma ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Mutation ; Lymphoma, Large B-Cell, Diffuse -- Genetics ; Mediastinal Neoplasms -- Genetics ; Nf-Kappa B -- Metabolism ; Polycomb Repressive Complex 2 -- Genetics
    ISSN: 02507005
    E-ISSN: 1791-7530
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 6
    Language: English
    In: British Journal of Haematology, 2019, Vol.184(5), p.869(5)
    Description: Byline: Hanno Witte, Harald Biersack, Svenja Kopelke, Dirk Rades, Hartmut Merz, Veronica Bernard, Hendrik Lehnert, Sebastian Fetscher,Niklas Gebauer Keywords: Inflammation-based prognostic scores; Glasgow prognostic score; classical Hodgkin lymphoma; prognosis ***** No abstract is available for this article. ***** Article Note: Contributed equally to this study. Shared senior authorship. CAPTION(S): Fig S1. Flowchart depicting the composition of the study group Fig S2. Definition of optimal cut-off values for PLR (262ae8 - A) and NLR (6ae267 - B) utilizing a mixture model of two Gaussian distributions fitted to the histogram of the respective biomarker employing the R-based web-application by Budczies et al (Budczies et al, [Budczies, J., 2012]). Table S1. Clinicopathological baseline characteristics of the study group Table S2. Baseline clinical characteristics stratified on Glasgow prognostic score - and Neutrophil-to-lymphocyte ratio -group
    Keywords: Glasgow Prognostic Score ; Inflammation-Based Prognostic Scores ; Classical Hodgkin Lymphoma ; Prognosis;
    ISSN: 0007-1048
    E-ISSN: 13652141
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  • 7
    Language: English
    In: Nuclear Inst. and Methods in Physics Research, A, 11 March 2013, Vol.704, pp.7-13
    Description: The RF power for the superconducting 1.3 GHz CW LINAC “ELBE” has been doubled from less than 10 kW to 20 kW per cavity. In January 2012 the four 10 kW klystrons used to drive the four superconducting cavities of the LINAC have been replaced by pairs of 10 kW solid state power amplifiers (SSPA). ELBE is now worldwide the first 1.3 GHz CW LINAC equipped with solid state RF power amplifiers. This technical note details on this project. ► We report the first installation of 10 kW solid state RF-amplifiers at 1.3 GHz CW LINAC. ► The sc. cavities of “ELBE” are now driven by a pair of 10 kW solid state amplifiers (SSPA). ► The RF-power upgrade allows doubling the electron beam current (CW). ► Advantages of the new RF system are high reliability, easy service and lower costs.
    Keywords: Solid State Rf Power Amplifiers ; Superconducting CW Rf ; 1.3 Ghz Solid State Rf-Power Amplifiers ; Elbe-Rf ; Superconducting Linac Rf ; Physics
    ISSN: 0168-9002
    E-ISSN: 1872-9576
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  • 8
    In: Nature Genetics, 1994, Vol.6(1), p.70
    Description: We have analysed 118 families with inherited medullary thyroid carcinoma (MTC) for mutations of the RET proto-oncogene. These included cases of multiple endocrine neoplasia types 2A (MEN 2A) and 2B (MEN 2B) and familial MTC (FMTC). Mutations at one of 5 cysteines in the extracellular domain were found in 97% of patients with MEN 2A and 86% with FMTC but not in MEN 2B patients or normal controls. 84% of the MEN2A mutations affected codon 634. MEN 2A patients with a Cys634 to Arg substitution had a greater risk of developing parathyroid disease than those with other codon 634 mutations. Our data show a strong correlation between disease phenotype and the nature and position of the RET mutation, suggesting that a simple, constitutive activation of the RET tyrosine kinase is unlikely to explain the events leading to MEN 2A and FMTC.
    Keywords: Drosophila Proteins ; Proto-Oncogenes ; Carcinoma, Medullary -- Genetics ; Multiple Endocrine Neoplasia -- Genetics ; Thyroid Neoplasms -- Genetics;
    ISSN: 1061-4036
    E-ISSN: 1546-1718
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  • 9
    Language: English
    Description: Since January 2012 the Superconducting CW Linac ELBE is equipped and in permanent operation with four 20 kW Solid State Amplifier Blocks. The poster gives an overview on the design of the new RF system and the experience gained within the first two years of operation....
    Keywords: Accelerator Physics ; Accelerator Technology Main Systems ; T08 Rf Power Sources
    ISBN: 978-3-95450-132-8
    Source: DataCite
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  • 10
    In: Clinical Endocrinology, December 2006, Vol.65(6), pp.699-705
    Description: Following recent advances in the genetics of phaeochromocytomas and paragangliomas, the members of the European Network for the Study of Adrenal Tumours (ENS@T) Phaeochromocytoma Working Group have decided to share their genotyping data and to propose European recommendations for phaeochromocytoma/functional paraganglioma (PH/FPGL) genetic testing. Germline DNA from 642 patients was analysed by ENS@T teams. In 166 patients (25·9%) the disease was familial and caused by germline mutations in (56), (34), (31), (31) or (14), causing von Hippel‐Lindau disease, SDHB‐ or SDHD‐PH/FPGL syndromes, multiple endocrine neoplasia type 2 (MEN 2) and type 1 neurofibromatosis (NF1), respectively. In almost 60% of inherited cases it was possible to formulate a probable genetic diagnosis based on family history and/or typical syndromic presentation. Genetic testing revealed mutations in 12·7% of cases with an apparently sporadic presentation. Several clinical characteristics, such as young age at onset, the presence of bilateral, extra‐adrenal or multiple tumours or a malignant tumour, should be seen as indications for genetic testing. The ENS@T Phaeochromocytoma Working Group recommends the genetic testing of all patients with PH and FPGL and suggests a practice algorithm for the management of their exploration.
    Keywords: Algorithms ; Genetic Research;
    ISSN: 0300-0664
    E-ISSN: 1365-2265
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