UID:
almafu_9958097424702883
Format:
1 online resource (255 p.)
ISBN:
1-281-01958-5
,
9786611019587
,
0-08-052670-5
Series Statement:
Advances in drug research ; v. 27, 1996
Content:
Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.
Note:
Description based upon print version of record.
,
Cover; Copyright Page; Contents; Contributors; Foreword; Preface; Abbreviations; Introduction; Chapter 1. Regulation of Glucose Homoeostasis; 1 Introduction; 2 Effect of Insulin Deficiency; 3 Regulation of Glucose Homoeostatis in Type-I Diabetes Mellitus (IDDM); 4 Regulation of Glucose Homoeostasis in Type-II Diabetes Mellitus (NIDDM); Chapter 2. Clinical Aspects of Diabetes Mellitus; 1 Type-I Diabetes Mellitus; 2 Type-II Diabetes Mellitus; Chapter 3. Mechanisms of Insulin Action; 1 Insulin Actions; 2 Insulin Receptor; 3 Signal Transduction
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4 Effector Systems of Insulin Signals: A Limited SelectionChapter 4. Therapeutic Use of Insulin; 1 Chemistry; 2 Preparations; 3 Application of Insulins; 4 Pharmacokinetics; 5 Toxic Effects; 6 Side Effects; 7 Clinical Studies of Insulin-replacement Therapy; Chapter 5. The Secretory Machinery of Insulin Release; 1 Introduction; 2 Route by which Initiators and Modulators Reach the B-Cell; 3 Initiation of Insulin Secretion; 4 Modulation of Insulin Secretion via Adenylate Cyclase and Phospholipase C (PLC); 5 Concept of Initiation and Modulation of Insulin Secretion
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Chapter 6. Compounds Acting on Insulin Secretion: Sulphonylureas1 Chemical Structure; 2 Actions; 3 Pharmacokinetics; 4 Toxic Effects; 5 Side Effects; 6 Interaction with Other Drugs; 7 Clinical Studies; Chapter 7. Compounds Acting on Glucose Absorption; 1 Guar; 2 Acarbose; Chapter 8. Aldose Reductase Inhibitors as New Antidiabetic Drugs; 1 Chemistry; 2 Functions of Aldose Reductase; 3 Action of Aldose Reductase Inhibitors; 4 Pharmacokinetics; 5 Pathological Changes in the Pharmacokinetics; 6 Toxic and Side Effects; 7 Interaction with Other Drugs; 8 Clinical Trials; Conclusions; References
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Subject IndexCumulative Index of Authors; Cumulative Index of Titles
,
English
Additional Edition:
ISBN 0-12-013327-X
Language:
English
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