UID:
almafu_9960073133802883
Umfang:
1 online resource (553 p.)
ISBN:
1-281-11891-5
,
9786611118914
,
0-08-053390-6
Inhalt:
This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins.Key Features* Covers cellular metabolism of he
Anmerkung:
Description based upon print version of record.
,
Front Cover; Heparin-Binding Proteins; Copyright Page; Table of Contents; Preface; Conventions, Abbreviation, and Terminology; Chapter 1. Heparin vs Heparan Sulfate; I. Background; II. Heparinoids Defined; III. The Ubiquity of Heparinoids in Animal Cells; IV. Heparin-Binding Proteins; V. Heparin Binding to Antithrombin: the Protototype for Heparin-Binding Proteins; VI. Theme; Chapter 2. Structures of Heparinoids; I. The Composition of Heparinoids; Il. Heparin and Heparaa Sulfate Structures; III. Biosynthesis of Heparinoids: What it Teaches about Structures
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IV. The Size and Variability of HeparinoidsV. The Shape of Heparinoids; VI. Proteoglycan Forms of Heparinoids; Additional References; Chapter 3. Determination of Hepaeinoid Structures; I. Introduction; II. Acid Hydrolysis and Monosaccharide Analysis; Ill. Cleavage of Heparin with Retention of Sulfate Substituents; IV. Determination of Oligosacchadde Structures; V. Determination of Molecular Weight; VI Physical Methods in Heparinoid Structural Studies; VII Use of Antibodies; Additional References; Chapter 4. Structural Modification of Heparinoids; I. Modification of Polymeric Heparinoids
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II. Modified Heparinoids in Structural and Biological StudiesllI. Synthesis of Oligosaccharides; Additional References; Chapter 5. The Cellular Metabolism of Heparan Sulfate Proteoglycans; I. Overview; II. Methods for Studying Proteoglycan Metabolism; III. Metabolism of Heparan Sulfate Proteoglycans; IV. Perturbation of Heparinoid Metabolism; V. Metabolism of Exogenous Heparinoids; VI. Dynamic Aspects of HSPG Metabolism--a Key to its Function?; Additional References; Chapter 6. Heparionoid/Protein Interactions; I. Aspects of Heparinoid/Protein Interactions
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lI. Heparinoids and Proteins. Partners in BindingIlI. The Binding of Metal Ions by Heparinoids; IV. Methodology; Additional References; Chapter 7. Antithrombin, The Prototypic Heparin-Binding Protein; I. The Heparin/Antithrombin Interaction; II. The Role of Antithrombin in Vivo; Ill. Antithrombin and Thrombin as Prototypes for Heparin-Binding Proteins; Additional References; Chapter 8. Heparin-Binding Proteins in Hemostasis; I. Hemostasis; II. Interactions of Heparinoids with the Heparin-Binding Proteins in Hemostasis; IlI. Summary; Additional References; Chapter 9. Fibroblast Growth Factors
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I. IntroductionII. FGF Structures and Properties; IlI. Metabolism of FGFs; IV. Interaction of Heparinoids with FGFs and their Receptors; V. Involvement of lteparinoids in FGF Metabolism: Caveats; VI. Summary; Additional References; Chapter 10. Extracellular Superoxide Dismutase; I. Superoxide Generation during the Inflammation Process; II. Superoxide Dismutase Isozymes; III. The Structure of EC-SOD; IV. Metabolism of EC-SOD; V .HSPG in the Regulation of EC-SOD Activity; Additional References; Chapter 11. Heparin-Binding Proteins in Lipoprotein Metabolism; I. Overview; II. Lipases
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IlI. Heparin Binding Lipases
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English
Weitere Ausg.:
ISBN 0-12-186060-4
Sprache:
Englisch
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