UID:
almahu_9948026444702882
Format:
1 online resource (527 p.)
ISBN:
1-281-03712-5
,
9786611037123
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0-08-053859-2
Content:
In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries.In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broa
Note:
Description based upon print version of record.
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Front Cover; Peptides: Synthesis, Structures, and Applications; Copyright Page; Contents; Contributors; Preface; Chapter 1. The History of Peptide Chemistry; I. Introduction; II. Early Peptide Syntheses; III. A New Era in Peptide Chemistry; IV. Classic Peptide Syntheses; V. Conclusion; References; Chapter 2. Amide Formation, Deprotection, and Disulfide Formation in Peptide Synthesis; I. Amide-Forming Reactions; II. Deprotection; III. Disulfide Bond Formation; Abbreviations; References; Chapter 3. Solid-Phase Peptide Synthesis; I. Introduction; II. The Solid Support
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III. Handles, Linkers, and SpacersIV. Protecting Group Strategy; V. The Coupling Reaction; VI. Cause and Correction of Incomplete Coupling Reactions; VII. The Cleavage Reaction; VIII. Solid-Phase Synthesis of Peptides and Proteins; Abbreviations; References; Chapter 4. a-Helix Formation by Peptides in Water; I. Introduction; II. Methods of Studying Helix Formation; III. Models for Helix-Coil Transitio; IV. Helix Propensities; V. Side-Chain Interactions; VI. Capping Interactions; VII. Protein Helices; References; Chapter 5. Peptide Conformation: Stability and Dynamics; I. Introduction
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II. Theoretical StudiesIII. Experimental Analysis; IV. Goal-Directed Modifications of Conformational Flexibility; V. Examples of Experimental and Computational Techniques Applied to the Study of Peptide Conformational Stability and Dynamics; References; Chapter 6. Structure-Function Studies of Peptide Hormones: An Overview; I. Introduction; II. Mammalian Peptide Hormones; III. Use of Classic Structure-Function Studies: General Considerations; IV. Use of Conformational Constraints: General Considerations; V. Selected Examples to Illustrate Approaches; VI. Summary and Conclusions; References
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Chapter 7. Neuropeptides: Peptide and Nonpeptide AnalogsI. Biosynthesis of Neuropeptides; II. Neuropeptide Receptors; III. Opioids; IV. Tachykinins; V. Angiotensin II; VI. Oxytocin and Vasopressin; VII. Cholecystokinin; VIII. Conclusions; References; Chapter 8. Reversible Inhibitors of Serine Proteinases:Naturally Occurring Miniproteins, Semisynthetic Variants, Recombinant Homologs, and Synthetic Peptides; I. Introduction; II. Serine Proteinase-Inhibitor Interactions; III. Naturally Occurring Proteinase Inhibitors; IV. Semisynthetic Proteinase Inhibitors
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V. Proteinase Inhibitors by Genetic EngineeringVI. Chemically Synthesized Proteinase Inhibitors and Fragments; VII. Concluding Remarks and Outlook; References; Chapter 9. Design of Polypeptides; I. Introduction; II. Recent Design Activities; III. Polypeptide Design: Quo Vadis?; References; Chapter 10. Soluble Chemical Combinatorial Libraries: Current Capabilities and Future Possibilities; I. Introduction; II. Classes and Applications of Soluble Combinatorial Libraries of Peptides; III. Applications of Soluble Peptide Libraries; IV. Conclusion; References
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Chapter 11. Epitope Mapping with Peptides
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English
Additional Edition:
ISBN 0-12-310920-5
Language:
English
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