UID:
almahu_9948026007002882
Umfang:
1 online resource (1023 p.)
Ausgabe:
1st ed.
ISBN:
1-281-02326-4
,
9786611023263
,
0-08-052503-2
Inhalt:
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems.NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present i
Anmerkung:
Description based upon print version of record.
,
Front Cover; Nitric Oxide Biology and Pathobiology; Copyright Page; Contents; Contributors; Preface; Section I: Overview of Basic Principles; Chapter 1. Introduction and Overview; Section II: Principles of Biology; Chapter 2. The Chemical Properties of Nitric Oxide and Related Nitrogen Oxides; Chapter 3. The Chemical Biology of Nitric Oxide; Chapter 4. The Biological Chemistry of Peroxynitrite; Chapter 5. A Comparison of the Biological Reactivity of Nitric Oxide and Peroxynitrite; Chapter 6. Structural Variations to Accommodate Functional Themes of the Isoforms of NO Synthases
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Chapter 7. Regulation of the Expression of Nitric Oxide Synthase IsoformsChapter 8. Molecular Regulation of Inducible Nitric Oxide Synthase; Chapter 9. Molecular Control of Endothelial Derived Nitric Oxide. A New Paradigm for Endothelial NOS Regulation by Posttranslational Modification; Chapter 10. Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role; Chapter 11. Regulation of Arginine Availability and Its Impact on NO Synthesis; Chapter 12. Relationship between Arginase Activity and Nitric Oxide Production
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Chapter 13. The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in TissueChapter 14. Membrane Transport of Arginine and Cationic Amino Acid Analogs; Chapter 15. The Respiratory Cycle: A Three-Gas System; Chapter 16. Role for Nitric Oxide and Other Radicals in Signal Transduction; Chapter 17. Antioxidant Actions of Nitric Oxide; Chapter 18. Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiological Signaling Systems; Chapter 19. Nitric Oxide, Oxygen Radicals, and Iron Metabolism
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Chapter 20. Redox Modulation of Iron Regulatory Proteins by Nitric Oxide and PeroxynitriteChapter 21. Nitric Oxide, Oxidative Stress, and Signal Transduction; Chapter 22. Mechanisms of Antioxidant Defense against Nitric Oxide/Peroxynitrite; Chapter 23. Regulation of Oxygen Metabolism by Nitric Oxide; Chapter 24. Structure-Function Relationships in NO-Sensitive Guanylyl Cyclase; Chapter 25. Mechanism of Activation of Soluble Guanylyl Cyclase by NO: Allosteric Regulation through Changes in Heme Coordination Geometry; Chapter 26. Cyclic GMP-Mediated Signaling Mechanisms in Smooth Muscle
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Section III: Principles of PathobiologyChapter 27. Influence of Nitric Oxide on Neuroendocrine Function and Behavior; Chapter 28. Nitric Oxide and Cerebral Ischemia; Chapter 29. Role of Nitric Oxide in Neuronal Protection versus Apoptosis; Chapter 30. Nitric Oxide and Autoimmune Disease in the Nervous System: Pathobiology of Inflammation and Demyelination; Chapter 31. Role of Nitric Oxide in the Regulation of Blood Flow; Chapter 32. Nitric Oxide Synthase Gene Transfer; Chapter 33. Functional Influence of Gene Transfer of Recombinant Nitric Oxide Synthase to Cardiovascular System
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Chapter 34. Nitric Oxide and Vascular Endothelial Dysfunction
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English
Weitere Ausg.:
ISBN 0-12-370420-0
Sprache:
Englisch
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