Format:
Online Ressource (xvi, 434 p.)
,
ill.
Edition:
1st ed.
Edition:
Online-Ausg.
ISBN:
0080919456
,
9780123705815
,
0123705819
,
9780080919454
,
9781282953949
,
128295394X
Content:
Part I: Fourier Transforms -- Part II: Optics -- Part III: Further Mathematical Methods/General Aspects -- Part IV: Image Analysis/Structure Determination
Content:
Structural Biology Using Electrons and X-rays is the perfect book to provide advanced undergraduates or graduate students with an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starting with Fourier transforms and progressing through optics and imaging principles, symmetry and three-dimensional reconstruction theory, Structural Biology Using Electrons and X-rays ends in an account of the latest methods adapted to crystals, helices, viral heads, and single particles. *Emphasis on common principles underlying all diffraction-based methods *Thorough grounding in theory requires understanding of only simple algebra *Visual representations and explanations of challenging content *Mathematical detail offered in short-course form to parallel the text
Note:
Includes bibliographical references (p. 417-425) and index. - Description based on print version record
,
Front Cover; Structural Biology Using Electrons and X-Rays; Copyright Page; Contents; Preface; Chapter 1: Overview; 1.1 Role of Structural (Molecular) Biology; 1.2 A Short History of Structural (Molecular) Biology; PART I: FOURIER TRANSFORMS; Chapter 2: Correlations and Convolutions; 2.1 Introducing Correlations; 2.2 Function Parity; 2.3 Auto-Correlation Function; Chapter 3: Fourier Fundamentals; 3.1 Component Functions; 3.2 Fourier Analysis of Periodic Even Functions; 3.3 Sines and Phasors; 3.4 Fourier Transforms; 3.5 Summary of Rules; Chapter 4: Digital Fourier Transforms
,
4.1 Data Preparation4.2 Digital Fourier Transform Features; 4.3 Digital Fourier Transform Calculations; 4.4 Appendix; Chapter 5: Filters; 5.1 Introduction; 5.2 Blurring Filters; 5.3 Digital-to-Analog Conversion; 5.4 Correcting Blurring Filters; 5.5 Gradients and Derivatives; Chapter 6: Two-Dimensional FTs; 6.1 Two-Dimensional Fourier Transforms Rules; 6.2 Points and Lines; 6.3 Polygons; 6.4 Polar Coordinates; PART II: OPTICS; Chapter 7: Microscopy with Rays; 7.1 Light Microscopy; 7.2 Electron Microscopy; 7.3 Electron Lens Aberrations; 7.4 Contrast Mechanisms; Chapter 8: Waves
,
8.1 Wave Properties8.2 The Quantum Electron; 8.3 Fresnel Diffraction; 8.4 Fraunhofer Diffraction; 8.5 Appendix; Chapter 9: Wave Imaging; 9.1 Overview of Wave Imaging; 9.2 Defocus; 9.3 Other Aberrations; 9.4 Appendix: Aberration Phase-Shift Geometry; PART III: GENERAL STRUCTURAL METHODS; Chapter 10: Symmetry; 10.1 Principles; 10.2 One-Translation Groups; 10.3 Two-Translation Groups; 10.4 Three-Translation Groups; 10.5 Fourier Transforms of Crystallographic Symmetry Operations; Chapter 11: Statistics and Matrices; 11.1 Statistics; 11.2 Matrices; 11.3 Structure Optimization and Simulation
,
11.4 AppendixChapter 12: The Third Dimension; 12.1 Depth Through Tilting; 12.2 Aligning Particle Images; 12.3 Information Content of Particle Images; 12.4 Three-Dimensional Reconstruction: Principles; PART IV: SYMMETRY-BASED METHODS; Chapter 13: X-Ray Crystallography; 13.1 Introduction; 13.2 Specimen and Data Collection; 13.3 Ab Initio Phasing; 13.4 Other Phasing Methods; Chapter 14: Crystalline Sheets; 14.1 Electrons Versus X-Rays; 14.2 Electron Diffraction; 14.3 Two-Dimensional Imaging; 14.4 Three-Dimensional Imaging; Chapter 15: Helices; 15.1 Helical Symmetry and Structure
,
15.2 Helical Fourier Transforms15.3 Getting a Structure from Helical Diffraction Data; Chapter 16: Icosahedral Particles; 16.1 Deltahedra; 16.2 Projections; 16.3 Three-Dimensional Reconstruction; 16.4 Appendix: Calculation of T-numbers; Chapter 17: Unsymmetrical ('Single') Particles; 17.1 Introduction; 17.2 Alignment; 17.3 Multivariate Statistical Analysis; 17.4 Reconstruction; Chapter 18: Distortion Correction; 18.1 Introduction; 18.2 Crystalline Sheets; 18.3 Helices; PART V: MATHEMATICAL BASIS; Chapter 19: FT Mathematics; 19.1 Introduction; 19.2 Algebra; 19.3 Geometry; 19.4 Infinitesimals
,
19.5 Calculus
Additional Edition:
ISBN 0080919456
Additional Edition:
Druckausg. Moody, Michael F. Structural biology using electrons and X-rays London [u.a.] : Academic Press, 2011 ISBN 9780123705815
Additional Edition:
ISBN 0123705819
Language:
English
Keywords:
Molekularbiologie
;
Molekülstruktur
;
Untersuchungsmethode
;
Molekularbiologie
;
Molekülstruktur
;
Untersuchungsmethode
;
Electronic book
;
Electronic books
DOI:
10.1016/C2009-0-01500-1
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