UID:
almahu_9948026154702882
Format:
1 online resource (491 p.)
ISBN:
1-280-63593-2
,
9786610635931
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0-08-046400-9
Series Statement:
Interface science and technology ; v. 8
Content:
Tissue engineering is an emerging interdisciplinary field, occupying a major position in the regenerative medicine that aims at restoring lost or damaged tissues and organs with use of cells. Regenerative medicine includes cellular therapy and tissue engineering. In general, the former treats patients by cell infusion alone, while tissue engineering needs biomaterials and growth factors in addition to cells. Biomaterials function in tissue engineering as the scaffold or template for cells to proliferate, differentiate, and produce matrices. This book focuses on the fundamentals (biomaterials,
Note:
Description based upon print version of record.
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Front Cover; Table of Contents; Preface; List of Abbreviations; CHAPTER 1: SCOPE OF TISSUE ENGINEERING; 1. Functions of Scaffold; 2. Absorbable Biomaterials; 2.1. Natural Polymers; 2.1.1. Proteins; 2.1.2. Polysaccharides; 2.1.3. Natural Composite-ECM; 2.2. Synthetic Polymers; 2.2.1. Poly(alpha-hydroxyacid)s [Aliphatic alpha-polyesters or Poly(alpha-hydroxyester)s]; 2.2.2. Hydrogels; 2.2.3. Others; 2.3. Inorganic Materials-Calcium Phosphate; 2.4. Composite Materials; 3. Pore Creation in Biomaterials; 3.1. Phase Separation (Freeze Drying); 3.2. Porogen Leaching; 3.3. Fiber Bonding
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3.4. Gas Foaming3.5. Rapid Prototyping; 3.6. Electrospinning; 4. Special Scaffolds; 4.1. Naturally Derived Scaffolds; 4.1.1. ECM-like Scaffolds; 4.1.2. Fibrin Gel; 4.1.3. MatrigelTM; 4.1.4. Marine Natural Scaffold; 4.2. Injectable Scaffolds; 4.3. Soft, Elastic Scaffolds; 4.4. Inorganic Scaffolds; 4.5. Composite Scaffolds; 5. Surface Modifications; 5.1. Cell Interactions in Natural Tissues; 5.2. Artificial Surface in Biological Environment; 6. Cell Expansion and Differentiation; 6.1. Monolayer (2-D) and 3-D Culture; 6.2. Cell Seeding; 6.2.1. Serum; 6.2.2. Cell Adhesion
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6.2.3. Seeding Efficiency6.2.4. Assessment of Cells in Scaffolds; 6.2.5. Gene Expression of Cells; 6.3. Bioreactors; 6.3.1. Spinner Flask; 6.3.2. Perfusion System; 6.3.3. Rotating Wall Reactor; 6.3.4. Kinetics; 6.4. Externally Applied Mechanical Stimulation; 6.5. Neovascularization; 7. Growth Factors; 7.1. Representative Growth Factors; 7.1.1. BMPs; 7.1.2. FGFs; 7.1.3. VEGF; 7.1.4. TGF-beta1; 7.1.5. PDGF; 7.2. Delivery of Growth Factors; 8. Cell Sources; 8.1. Differentiated Cells; 8.2. Somatic (Adult) Stem Cells; 8.2.1. MSCs; 8.2.2. Adipose-Derived Stem Cells
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8.2.3. Umbilical Cord Blood-Derived Cells8.3. Cell Therapy; 8.3.1. Angiogenesis; 8.3.2. Cardiac Malfunction; 8.4. ES Cells; 8.4.1. Cell Expansion and Differentiation; 8.4.2. Somatic Cell Nuclear Transfer; References; CHAPTER 2: ANIMAL AND HUMAN TRIALS OF ENGINEERED TISSUES; 1. Body Surface System; 1.1. Skin; 1.1.1. Without Cells; 1.1.2. Keratinocytes; 1.1.3. Keratinocytes on Acellular Dermis; 1.1.4. Keratinocytes + Fibroblasts; 1.1.5. Keratinocytes + Melanocytes; 1.1.6. Stem Cell Transplantation; 1.2. Auricular and Nasoseptal Cartilages; 1.3. Adipose Tissue; 2. Musculoskeletal System
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2.1. Articular Cartilage2.2. Bones; 2.3. Tendon and Ligament; 2.3.1. Ligaments; 2.3.2. Tendons; 2.4. Rotator Cuff; 2.5. Skeletal Muscle; 2.6. Joints; 2.6.1. Large Joints; 2.6.2. Small Joints: Phalangeal Joints; 3. Cardiovascular and Thoracic System; 3.1. Blood Vessels; 3.1.1. Large-Calibered Blood Vessels; 3.1.2. Coronary Artery; 3.1.3. Angiogenesis; 3.1.4. Neovascularization; 3.2. Heart Valves; 3.3. Myocardial Tissue; 3.4. Trachea; 4. Nervous System; 4.1. Neuron; 4.2. Spinal Cord; 4.3. Peripheral Nerve; 5. Maxillofacial System; 5.1. Alveolar Bone and Periodontium
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5.2. Temporomandibular Joint
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English
Additional Edition:
ISBN 0-12-370582-7
Language:
English
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