UID:
almahu_9948025726702882
Format:
1 online resource (507 p.)
ISBN:
1-282-73731-7
,
9786612737312
,
0-08-092005-5
Content:
This handbook provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell (""the glycome""). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approach
Note:
Description based upon print version of record.
,
Front Cover; Handbook of Glycomics; Copyright Page; Contents; List of Contributors; Preface; Acknowledgments; Section I: Glycoconjugate Structural Analysis; Chapter 1. High-Sensitivity Analytical Approaches to the Analysis of N-Glycans; Introduction; Release of N-Glycans from Glycoproteins; Purification of N-Glycans; Analysis of Glycan Mixtures; Conclusions; References; Chapter 2. O-Glycan Complexity and Analysis; Introduction; O-Glycan Complexity; Analysis of Released O-Glycans; Analysis of O-Glycopeptides; Conclusions; References; Chapter 3. Glycosaminoglycans; Introduction
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Isolation of GAGsPurification of Individual GAGs; Structure Analysis; Conclusion; References; Section II: Glycotranscriptomics; Chapter 4. Isotopic Labeling of Glycans for Quantitative Glycomics; Introduction; Overall Strategy of Isotope Labeling of Glycans for Quantitative Glycomics; Isotope-Coded Reagents for Glycan Analyses and Analytical Approaches; Concluding Remarks; References; Chapter 5. Glycotranscriptomics; Introduction; Overview of Glycan Biosynthesis in Animal Systems; Identification of Genes Involved in Glycan Biosynthesis
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Overview of Transcript Analysis and Gene Expression MethodsAnalysis of Gene Expression Data; Examples of Correlation of Transcript Analysis Data with Protein and Structural Data; Future Directions; References; Section III: Protein-Glycan Interactions; Chapter 6. Glycan-Binding Proteins and Glycan Microarrays; Introduction; Construction of Glycan Microarrays; Overall Strategy of Glycan Arrays: the Big Picture; Methods for Detecting Binding of GBPs to Glycan Arrays; Collection and Presentation of Data from a Large Glycan Microarray
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Use of Glycan Arrays to Investigate Specificity of Glycan-Binding ProteinsVirus Binding to Glycan Arrays; Limitations of Glycan Arrays; Concluding Remarks; References; Chapter 7. Chromatographic and Mass Spectrometric Techniques; Current Status of Understanding about Glycans; Basic Approaches to Structural Glycomics; The Use of Lectins in Structural Glycomics; Methods for Interaction Analysis of Lectins and Glycans: A Basis of Lectin Study; Concluding Remarks; References; Section IV: Glycobioinformatics; Chapter 8. Integration of Glycomics Knowledge and Data; Background and Motivation
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Bioinformatic Approaches to GlycobiologyConclusions; References; Chapter 9. KEGG GLYCAN for Integrated Analysis of Pathways, Genes, and Glycan Structures; Introduction; Glycan Biosynthesis and Metabolism; Genes Related to Glycan Biosynthesis; Glycan Structures; Bioinformatics Approach to Glycomics Research; Algorithms for Feature Extraction of Glycan Structures; Concluding Remarks; References; Chapter 10. Carbohydrate Structure Databases; Introduction; Current Established Carbohydrate Structure Databases; New Database Initiatives; Case Studies; Conclusion and Outlook; References
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Section V: Glycomes
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English
Additional Edition:
ISBN 0-12-373600-5
Language:
English
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