Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (600 p.)

Edition: 1st ed.

ISBN: 1-282-28674-9

Content: Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the ch

Note: Description based upon print version of record. , Front Cover; Clinical and Translational Science; Copyright Page; Contents; List of contributors; Foreword; Acknowledgments; Introduction to Clinical Research; HISTORICAL BACKGROUND; ORGANIZATION OF THIS BOOK; REFERENCES; Part I: Fundamental Principles; Chapter 1 Patient-Oriented Research: Clinical Pathophysiology and Clinical Therapeutics; INTRODUCTION; TYPES OF PATIENT-ORIENTED RESEARCH; THE ROLE OF PATIENT-ORIENTED RESEARCH IN TRANSLATIONAL RESEARCH; SEQUENCE OF INVESTIGATION; CONCLUSIONS; REFERENCES; Chapter 2 Clinical Trials; INTRODUCTION; HISTORY; PHASES OF EVALUATION OF THERAPIES , CRITICAL GENERAL CONCEPTSEXPRESSING CLINICAL TRIAL RESULTS; CONCEPTS UNDERLYING TRIAL DESIGN; GENERAL DESIGN CONSIDERATIONS; LEGAL AND ETHICAL ISSUES; HYPOTHESIS FORMULATION; PUBLICATION BIAS; STATISTICAL CONSIDERATIONS; META-ANALYSIS AND SYSTEMATIC OVERVIEWS; UNDERSTANDING COVARIATES AND SUBGROUPS; THERAPEUTIC TRUISMS; STUDY ORGANIZATION; INTEGRATION INTO PRACTICE; THE FUTURE; ACKNOWLEDGMENT; REFERENCES; Part II: Approaches; Chapter 3 Experimental Design; INTRODUCTION; HYPOTHESIS DEVELOPMENT; STUDY DESIGN OPTIONS; CONTROL OF BIAS; SAMPLE SIZE; ENDPOINTS; DATA MANAGEMENT; STATISTICAL ANALYSIS , CONCLUSIONREFERENCES; Chapter 4 Introduction to Biostatistics Ideas; BIOSTATISTICS: WHAT IS IT?; EVIDENCE: HOW MANY HEADS ON THIS COIN?; POPULATIONS AND DISTRIBUTIONS; SAMPLES; CLINICAL MEASURES OF INTEREST: WHAT DO WE WANT TO KNOW?; DATA AS SAMPLES: DISPLAY, LOOK AND THINK; THE MOST IMPORTANT PROBABILITY MODEL IN MEDICINE; THE CIRCLE OF INFERENCE; CENTRAL LIMIT THEOREM (CLT); ESTIMATING THE TRUE POPULATION VALUE; TESTING PRE-SPECIFIED HYPOTHESES; THE MIGHTY P; REGRESSION ANALYSIS; THE MAIN POINTS ONCE AGAIN; REFERENCES; Chapter 5 Measurement of Biological Materials; INTRODUCTION , IMMUNOASSAYS AND IMMUNOCHEMISTRYRADIOIMMUNOASSAYS; CHROMATOGRAPHY; MASS SPECTROMETRY (MS); GENOMICS (GENE EXPRESSION MICROARRAYS); PROTEOMICS; METABOLOMICS; REFERENCES; Chapter 6 Imaging Tools in Human Research; INTRODUCTION; IMAGING TECHNOLOGIES: A BRIEF OVERVIEW; IMAGING TECHNOLOGIES: HUMANS AND SMALL ANIMALS; SUMMARY; ACKNOWLEDGMENTS; REFERENCE; Chapter 7 Imaging Tools in Cardiovascular Research; INTRODUCTION; IMAGING AND RISK STRATIFICATION; PRESSURE WAVEFORM ANALYSIS AND ARTERIAL STIFFNESS; ARTERIAL IMAGING; ULTRASOUND IMAGING OF THE HEART; SUMMARY; REFERENCES , Chapter 8 Nanotechnology in Clinical and Translational ResearchINTRODUCTION AND HISTORICAL PERSPECTIVE; NANOTECHNOLOGY IN BASIC RESEARCH APPLICATIONS SUPPORTING CLINICAL TRANSLATION; CLINICAL APPLICATIONS OF NANOTECHNOLOGY FOR RESEARCH; CONCLUSION AND FUTURE DIRECTIONS IN NANOMEDICINE; REFERENCES; Chapter 9 The Use of Questionnaires and Surveys; INTRODUCTION; THE PRACTICE OF QUESTIONNAIRE AND SURVEY MEASUREMENT; REFERENCES; Chapter 10 Information Technology; INTRODUCTION; CLINICAL DATA REPOSITORIES (CDRs); PRINCIPLES OF DATA WAREHOUSING , INFORMATION TECHNOLOGY SUPPORT OF PARTICIPANT RECRUITMENT , English

Additional Edition: ISBN 0-12-373639-0

Additional Edition: ISBN 0-08-092019-5

Language: English

UID:

Format: 1 online resource (xx, 763 pages) , illustrations (some color)

Edition: Second edition

ISBN: 9780128021118 , 012802111X

Content: Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science

Note: Revised edition of: Clinical and translational science : principles of human research / edited by David Robertson, Gordon H. Williams. 1st ed. 2009 , Includes bibliographical references

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780128021019

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 0128021012

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780123736390

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 0123736390

Language: English

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 Online-Ressource (XX, 579 S.) ; , Ill., graph. Darst.

ISBN: 978-0-08-092019-1 , 0-08-092019-5

Note: Clinical and translational science are fields devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. This book is designed as the most authoritative and up-to-date resource for the broad range of investigators in various medical specialties taking on the challenge of clinical and translational science. Prepared with an international perspective, Clinical and Translational Science begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, legal, social, and ethical issues of clinical research are discussed concluding with a discussion of future prospects to provide readers with a comprehensive view of this developing area of science. Discusses practical biological, physiological, cellular, and therapeutic applications for one of the fastest growing fields in private practice and academic medicine. Includes contributions from international leaders providing insight into background and future understanding for clinical and translational science. Presents the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. - Includes bibliographical references and index

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-0-12-373639-0

Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 0-12-373639-0

Language: English

DOI: 10.1016/B978-0-12-373639-0.X0001-5

URL: Volltext

URL: Volltext