Umfang:
1 Online-Ressource (502 Seiten)
ISBN:
0080878512
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9780080878515
,
0123747090
,
9780123747099
Inhalt:
Diffusion imaging is a non-invasive MR technique that is now being used in novel ways to study aspects of white matter anatomy that could never before be investigated in the living brain. The technique therefore has enormous potential for addressing novel research questions in both basic and clinical neuroscience. This book aims to cover the field of diffusion imaging from the fundamental theory to its most cutting-edge applications. It contains sufficient detail to be a reference book for medical physicists, but will also cover fundamental aspects of experimental design and example applications that will be of interest to clinical and basic neuroscientists. Importantly, the book presents diffusion imaging in the context of well-established, classical experimental techniques, so that readers will be able to assess the scope and limitations of the new imaging technology with respect to techniques available previously. Each section includes chapters on methodology (with the more advanced, mathematical material included in appendices for the interested reader), validation of the imaging technology, and application of diffusion imaging to the study of variation and development of normal brain anatomy, and disruption to the white matter in neurological disease or psychiatric disorder. The aim of the book is to become an essential reference text for scientists designing or interpreting diffusion MR experiments
Anmerkung:
Includes index
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Front Cover; Diffusion MRI: From Quantitative Measurement to In vivo Neuroanatomy; Copyright Page; Contents; Contributors; Foreword; Preface; Section I: Introduction to Diffusion MRI; Chapter 1. Introduction to Diffusion MR; I. WHAT IS DIFFUSION?; II. MAGNETIC RESONANCE AND DIFFUSION; III. DIFFUSION IN NEURAL TISSUE; IV. CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES; Chapter 2. Pulse Sequences for Diffusion-weighted MRI; I. MRI PULSE SEQUENCE PRIMER; II. ADDING DIFFUSION WEIGHTING TO A PULSE SEQUENCE; III. BULK MOTION SENSITIVITY; IV. SINGLE-SHOT EPI (SS-EPI) METHODS
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V. PARAMETER OPTIMIZATIONVI. OTHER DWI PULSE SEQUENCES; REFERENCES; Chapter 3. Gaussian Modeling of the Diffusion Signal; I. INTRODUCTION; II. DIFFUSION BASICS; III. BASIC MODELING AND QUANTIFICATION; IV. DATA ACQUISITION STRATEGIES; V. ARTIFACTS; REFERENCES; Chapter 4. Multiple Fibers: Beyond the Diffusion Tensor; I. INTRODUCTION; II. MULTIPLE FIBERS: WHAT'S ALL THE FUSS ABOUT?; III. MODEL-BASED APPROACHES; IV. NON-PARAMETRIC ALGORITHMS; V. DERIVED INFORMATION; VI. APPLICATIONS AND EXPLOITATION; VII. SUMMARY; ACKNOWLEDGMENTS; APPENDIX A. QBALL IMPLEMENTATION
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APPENDIX B. SPHERICAL DECONVOLUTION IMPLEMENTATIONREFERENCES; Section II: Diffusion MRI for Quantitative Measurement; Chapter 5. White Matter Structure: A Microscopist's View; I. INTRODUCTION; II. CELLULAR COMPONENTS OF THE CNS WHITE MATTER; III. WATER CONTENT OF WHITE MATTER; IV. CHANGES IN WHITE MATTER DUE TO ABNORMALITIES IN MYELIN; V. THE ULTRASTRUCTURAL EFFECTS OF DEMYELINATION AND AXONAL DAMAGE IN HUMANS; VI. SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 6. The Biological Basis of Diffusion Anisotropy; I. UTILITY OF MICROSCOPIC WATER MOTION
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II. RELATIONSHIP OF WATER DIFFUSION ANISOTROPY TO TISSUE MICROSTRUCTUREIII. ROLE OF THE APPARENT DIFFUSION COEFFICIENTS IN INTERPRETING ANISOTROPY; IV. ISSUES RELATED TO DIFFUSION ANISOTROPY MEASUREMENTS IN TISSUE BY MRI; V. SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 7. Inferring Microstructural Information of White Matter from Diffusion MRI; I. THE MORPHOLOGICAL FEATURES OF WHITE MATTER; II. DIFFUSION MRI AND TISSUE MICROSTRUCTURE; III. DIFFUSION TENSOR IMAGING - A TOOL FOR WHITE MATTER MICROSTRUCTURAL MAPPING
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IV. DIFFUSION TENSOR IMAGING - A TOOL FOR WHITE MATTER MICROSTRUCTURAL MAPPING?V. TYPES OF DIFFUSION PROCESSES IN THE TISSUE; VI. Q-SPACE ANALYSIS; VII. MODELS OF DIFFUSION IN WHITE MATTER; VIII. TOWARDS VIRTUAL BIOPSY OF WHITE MATTER WITH DIFFUSION MRI; REFERENCES; Chapter 8. Cross-subject Comparison of Local Diffusion MRI Parameters; I. INTRODUCTION; II. CROSS-SUBJECT REGISTRATION (IMAGE ALIGNMENT); III. VBM - OVERVIEW AND APPLICATION TO DIFFUSION DATA; IV. PROBLEMS OF INTERPRETABILITY IN VBM-STYLE ANALYSES; V. REGION-OF-INTEREST AND TRACTOGRAPHY-BASED STRATEGIES FOR LOCALIZING CHANGE
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VI. TRACT-BASED SPATIAL STATISTICS
Weitere Ausg.:
ISBN 0123747090
Weitere Ausg.:
ISBN 9780123747099
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Diffusion MRI Amsterdam ; Boston : Elsevier/Academic Press, 2009 ISBN 9780123747099
Weitere Ausg.:
ISBN 0123747090
Sprache:
Englisch
Schlagwort(e):
Electronic book
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