UID:
almahu_9947366658602882
Umfang:
1 online resource (305 p.)
Ausgabe:
1st ed.
ISBN:
1-282-87898-0
,
9786612878985
,
0-12-375675-8
Inhalt:
This book presents the essentials of behavioral test methodology needed for effective study planning and high quality behavioral data collection on laboratory mice. The broad scope of behavioral testing in relation to the neurosciences is discussed, as are the fine details of various test situations. Mistakes made in past research are scrutinized and lessons are drawn about how to avoid them in future work. Diverse factors that can influence the results of behavioral experiments are discussed, ranging from the specific parameters employed in a test to the laboratory environment outside the
Anmerkung:
Description based upon print version of record.
,
Front Cover; Mouse Behavioral Testing; Copyright; Contents; Preface; Acknowledgements; Chapter 1 Introduction to the Research Process; The Research Process: Scientific Aspects; The Institutional Context of Research; General References on Mice; Books on Behavioral Testing; Chapters and Review Articles on Mouse Behavior; Chapter 2 Mice; Mice Versus Rats; Models of Human Functions; Origins of Standard Mouse Strains; Kinds of Breeding Schemes; The Process of Close Inbreeding; Inbred Strains for Research; Special Genotypes Derived from Inbred Strains
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Designer Mice: Transgenic Methods and Targeted MutationsChapter 3 Tests of Mouse Behavior; Popularity of Tests; Commercial Devices; Exploration; Anxiety; Motor Function; Learning; Other Tests; Chapter 4 Designs; One Group; Two Groups; Matched Pairs; Repeated Measures; Single-Factor Study With More Than Two Groups (One-Way Design); Two-Factor Studies; Multi-Factor Studies; Specialized Designs; Complications; Utilities; Chapter 5 Sample Size; Utilities to do the Calculations; Population and Sample; Size of an Effect; Significance of an Effect; Power of a Test; Finding the Correct Sample Size
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Chapter 6 Ethics ApprovalGood Ethics and Good Science; The Era Before Regulation; The Era of Regulated Research With Animals; Ethical Status of Mice and Rats; The Fundamental Ethical Principle of Animal Research; The 3Rs; Case Studies; Categories of Invasiveness and Severity; Categories for Behavioral Tests Used with Mice; The Future; Chapter 7 Logistics; The Total Experiment; The Principle of Balancing and Randomization; The Total Sample Divided into Smaller Units; Throughput; Partitioning the Work Day; The Balancing Act; Randomization to the Rescue
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Shipments, Cages, Tail Marks, and Id NumbersCages in the Colony Room; The Data Sheet; Final Consultation; Other Examples; More Intricate Designs; Chapter 8 Getting Ready for Testing; Ordering Mice; Shipping; Unpacking; Marking for Individual Identification; Housing; Going to School: Test Day; Chapter 9 Prelude to Data Analysis; Know Your Object; Contents of One Row of Data; The Id Code; Order of Variables Across a Row; Naming Variables; The Value of Using the Right Values; The Plague Called Missing Data; Importing the Spreadsheet into the Statistical Program; Checking for Errors in the Data
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The Crucial Distinction Between Errors and ExceptionsLooking at Results; Statistical Data Analysis as a Final Step in the Process; Chapter 10 Domains and Test Batteries; Types of Observations; The Ethological Method; Domains and Subdomains; Complexity of Domains; Test Batteries; Chapter 11 Motivating Mice; Hunger and Food Deprivation; Electric Shock; Water Escape; Air Puff Aversion; Motivation and Learning; Chapter 12 Qualities of Behavioral Tests; Resolution, Accuracy, and Precision; Consistency; Reliability; Replicability; Validity; Chapter 13 Task Refinement and Standardization
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Flawed Tests and Missteps in the Research Process
,
English
Weitere Ausg.:
ISBN 0-12-375674-X
Sprache:
Englisch
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