Format:
Online-Ressource (xiv, 343 p., [2] p. of plates)
,
ill. (some col.)
,
29 cm
Edition:
1st ed
Edition:
Online-Ausg. Amsterdam Elsevier Science & Technology 2010 Electronic reproduction; Mode of access: World Wide Web
ISBN:
1282879952
,
9781282879959
,
0444535446
,
9780444535450
,
9780444535443
,
0444535454
Series Statement:
Neuroimmune biology v. 9
Content:
It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction which serves as an effector response for both the adaptive and innate immune systems Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus which is also the main director the hormonal regulation of immune/inflammatory. Gender related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioural conditioning (e.g. reward) of immune responses is possible, are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases
Content:
It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction which serves as an effector response for both the adaptive and innate immune systemsMechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus which is also the main director the hormonal regulation of immune/inflammatory. Gender related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioural conditioning (e.g. reward) of immune responses is possible, are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease* Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases
Note:
Includes bibliographical references and index
,
Front Cover; The Brain and Host Defense; Copyright Page; Contents; Foreword; Preface; List of Contributors; Section I: Introduction; Chapter 1 The Hypothalamus is the Central Organ of Immunoregulation; 1 INTRODUCTION; 2 SIGNALING THE HYPOTHALAMUS BY THE IMMUNE SYSTEM; 3 NEUROIMMUNOREGULATION DURING HOMEOSTASIS; 4 NEUROGENIC INFLAMMATION (NIF); 5 THE ACUTE PHASE RESPONSE (APR); 6 HEALING; 7 CONCLUSIONS; REFERENCES; Section II: Development and Function of the Neuroimmune System; Chapter 2 Leech Neuroimmune Signaling; 1 INTRODUCTION; 2 NEUROIMMUNE MODULATION BY OPIOIDS
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3 NEUROIMMUNE MODULATION BY OPIATES4 NEUROIMMUNE MODULATION BY CANNABINOIDS; 5 BRAIN INNATE IMMUNE RESPONSE; 6 CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3 Morphogenesis of the Hypothalamus and Hypophysis; 1 INTRODUCTION; 2 MORPHOLOGICAL ASPECTS OF PITUITARY DEVELOPMENT; 3 THE PITUITARY PRIMORDIUM AS A MEMBER OF THE CRANIAL PLACODES; 4 MOLECULAR ASPECTS OF THE DEVELOPMENT OF ADENOHYPOPHYSEAL PLACODE; 5 SIGNALING MOLECULES ACTING BEFORE AND AFTER THE FORMATION OF "RATHKE'S POUCH"; 6 TRANSCRIPTION FACTORS WORKING IN DEVELOPING PITUITARY CELLS
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7 ADENOHYPOPHYSIS AND ITS HOMOLOGS IN AGNATHAN VERTEBRATES AND PROTOCHORDATESREFERENCES; Chapter 4 A Novel Genus of Specialized Anti-Inflammatory and Pro-Resolution Lipid Mediators; 1 INFLAMMATION; 2 RESOLUTION OF SELF-LIMITED ACUTE INFLAMMATION; 3 ANTI-INFLAMMATORY AND PRO-RESOLUTION LIPID MEDIATORS; 4 RESOLVINS; 5 PROTECTINS AND D-SERIES RESOLVINS; 6 MARESINS; 7 CONCLUSIONS; 8 SUMMARY; ACKNOWLEDGEMENTS; REFERENCES; Chapter 5 Neural and Non-Neural Stem Cells as Novel Therapeutic Modalities for Brain Injury; 1 INTRODUCTION; 2 NEURAL STEM CELLS; 3 NON-NEURONAL (ADULT) STEM CELLS IN THE CNS
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REFERENCESChapter 6 The Role of the Toll-Like Receptors in Neuropathology; 1 INTRODUCTION; 2 IMMUNE-LINKED RECEPTORS IN THE BRAIN; 3 STRUCTURE OF TLRS; 4 TLR ADAPTOR PROTEINS; 5 STROKE/ISCHEMIC BRAIN DAMAGE; 6 INVADING PATHOGENS; 7 CANCER; 8 SPINAL CORD INJURY; 9 ALZHEIMER'S DISEASE; 10 MULTIPLE SCLEROSIS; 11 NEUROPATHIC PAIN; 12 CONCLUSIONS; REFERENCES; FURTHER READING; Chapter 7 Cytokines and the Immune-Neuroendocrine Network; 1 INTRODUCTION; N?????i???????????????????????????????????????????????????; 3 Th1 CYTOKINES IN THE NEUROIMMUNE NETWORK
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4 REGULATORY CYTOKINES IN THE NEUROIMMUNE NETWORK5 CYTOKINES AND MAJOR DEPRESSION; 6 CONCLUDING REMARKS; ACKNOWLEDGEMENTS; REFERENCES; Chapter 8 Orexin-Containing Neurons and the Immune System; 1 INTRODUCTION; 2 OREXIN AND OREXINERGIC NEURONS; 3 OREXINERGIC NEURON PROJECTIONS; 4 OREXIN RECEPTORS; 5 HYPOTHALAMIC OREXIN-CONTAINING NEURONS AND CYCLOPHOSPHAMIDE ADMINISTRATION; 6 OREXIN-CONTAINING NEURONS RESPOND TO ANTIGENIC CHALLENGES; CONCLUSION; REFERENCES; Chapter 9 Central Pathways of Immunoregulation; 1 CENTRAL PATHWAYS OF IMMUNOREGULATION
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E?????????????????u???C??????????????r????????????????????
,
The hypothalamus is the central organ of immunoregulation
,
Leech neuroimmune signaling
,
Morphogenesis of the hypothalamus and hypophysis
,
A novel genus of specialized anti-inflammatory and pro-resolution lipid mediators
,
Neural and non-neural stem cells as novel therapeutic modalities for brain injury
,
The role of the toll-like receptors in neuropathology
,
Cytokines and the immune-neuroendocrine network
,
Orexin-containing neurons and the immune system
,
Central pathways of immunoregulation
,
Brain responses to antigenic challenges
,
Role of the endocrine system
,
Conditioning of immune reactions
,
Gender issues in host defense
,
Glial cells in brain defense mechanisms
,
Immunologic privilege and the brain
,
Immune aspects of the blood-brain barrier
,
Neuroprotective activities of CD4+CD25+ regulatory T cells
,
Fever as a host defense mechanism
,
Leukocytes as mediator of pain and analgesia
,
Tumor necrosis factor as neuroinflammatory mediator in Alzheimer's disease and stroke: molecular mechanisms and neuroinflammatory imaging
,
21: Multiple sclerosis and depression : a neuroimmunological perspective
,
Infection and sepsis
,
Restoration of neuroimmune disturbances in rats by extra high frequency electromagnetic irradiation of the skin
,
Electronic reproduction; Mode of access: World Wide Web
Additional Edition:
ISBN 0123812763
Additional Edition:
Erscheint auch als Druck-Ausgabe The Brain and Host Defense
Language:
English
Keywords:
Electronic books
URL:
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