Kooperativer Bibliotheksverbund

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Format: 1 online resource (2250 p.)

Edition: 5th ed.

ISBN: 1-283-73509-1 , 0-12-382027-8

Content: The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical

Note: Description based upon print version of record. , Front Cover -- Physiology of the Gastrointestinal Tract -- Copyright Page -- Contents -- Contributors -- Preface to the First Edition -- Preface -- Acknowledgments -- Volume I -- Section I: Basic Cell Physiology, Genetics, and Growth of the GI Tract -- 1. Transcription and Epigenetic Regulation -- 1.1 Overview of Gene Organization -- 1.1.1 Nucleic Acids -- 1.1.2 Nucleic Acid Polymers: DNA, RNA -- 1.1.3 Gene Composition -- 1.1.4 RNA Species -- 1.1.5 Linking Gene Structure to Function -- 1.2 Epigenetic Influences -- 1.2.1 DNA Methylation -- 1.2.2 Histone Modifications -- 1.2.2.1 Histone Acetylation -- 1.2.2.2 Histone Methylation -- 1.2.2.2.1 Histone Methylation at Lysines -- 1.2.2.2.2 Histone Methylation at Arginines -- 1.2.3 Histone Phosphorylation -- 1.2.4 Chromatin Binding Proteins -- 1.2.5 Epigenetics and Development -- 1.2.6 Epigenetics and Cancer -- 1.3 Anatomy of a Gene Promoter -- 1.3.1 DNA Elements -- 1.3.2 DNA-binding Proteins -- 1.3.3 Co-regulatory Proteins -- 1.4 Methodology -- 1.4.1 Functional Methods -- 1.4.1.1 Reconstituted Transcription Systems -- 1.4.1.2 Cell Culture Models -- 1.4.1.3 Whole-animal Models -- 1.4.1.4 Transgenic Animals -- 1.4.1.5 Cell-based Knockout Strategies -- 1.4.2 Structural Methods -- 1.4.2.1 Chromatin Immunoprecipitation Assays -- 1.4.2.2 Microarray Technology -- 1.4.2.3 Next Generation Sequencing -- 1.4.2.4 Proteomics -- 1.4.2.5 Bioinformatics and Computational Biology -- 1.5 Transcriptional Control of Gastrointestinal Peptides -- 1.6 Post-Transcriptional Processing -- 1.6.1 Polyadenylation -- 1.6.2 RNA Splicing -- 1.6.2.1 The Spliceosome -- 1.6.2.2 Alternative Splicing -- 1.6.2.3 Regulated Post-transcriptional Mechanisms - mRNA Stability -- 1.6.2.4 Regulated Post-transcriptional Mechanisms - microRNAs -- 1.7 Transport Across the Nuclear Membrane -- 1.8 Concluding Remarks -- Acknowledgments -- References. , 2. Post-translational Processing of Gastrointestinal Peptides -- 2.1 Introduction -- 2.2 Translation and Passage into the Endoplasmic Reticulum -- 2.2.1 The Ribosome -- 2.2.2 Protein Folding in the Cytosol -- 2.2.3 The Signal Recognition Particle -- 2.3 Processing in the Endoplasmic Reticulum -- 2.3.1 Signal Peptidase Removal -- 2.3.2 Protein Folding in the ER -- 2.3.3 Disulfide Bond Formation -- 2.3.4 Asparagine-linked N-Glycosylation -- 2.3.5 Acylation -- 2.4 Sorting to the Golgi -- 2.5 Processing in the Golgi -- 2.5.1 Serine- or Threonine-linked O-Glycosylation -- 2.5.2 Sulfation -- 2.5.3 Phosphorylation -- 2.6 Sorting to the Secretory Vesicle -- 2.7 Processing in the Secretory Vesicle -- 2.7.1 Acetylation -- 2.7.2 Di-basic Cleavage -- 2.7.3 Mono-basic Cleavage -- 2.7.4 Aminopeptidase Cleavage -- 2.7.5 Glutaminyl Cyclase -- 2.7.6 Carboxypeptidase Cleavage -- 2.7.7 Amidation -- 2.8 Examples of Processing -- 2.8.1 Progastrin-releasing Peptide -- 2.8.2 Progastrin -- 2.8.3 Sonic Hedgehog -- 2.9 Summary -- References -- 3. Genetic Tools in Gastrointestinal Diseases -- 3.1 The Genetic Architecture of Mendelian and Non-Mendelian Diseases -- 3.2 Genome-Wide Association Studies -- 3.2.1 Common Disease, Common Variant Hypothesis -- 3.2.2 Disease Pathways, Population Differences, and Genetic Architecture of Complex Diseases -- 3.3 DNA Sequencing and Disease Association Studies of Uncommon Variants -- 3.4 DNA-RNA Translation Mappings -- 3.5 Epigenetic Regulation of Gene Expression -- 3.6 Integrating Genetic and Environmental Factors -- 3.7 Clinical Applications -- 3.8 Future Directions -- References -- 4. Signaling Pathways Induced by G-protein-coupled Receptors -- 4.1 Introduction -- 4.2 Gpcr Structure, Oligomerization, and Heterotrimeric G Proteins -- 4.3 GPCR Phosphorylation, Conformational Changes, Arrestin Recruitment, and G-Protein-Independent Signaling. , 4.3.1 Signaling Through Phospholipase C: Ca2+ Fluxes and Protein Kinase C -- 4.3.2 GPCR Signaling Through PKD -- 4.3.3 GPCR-induced ERK Activation: PKC-dependent and -independent Pathways -- 4.3.4 GPCR Signaling Through EGFR Transactivation -- 4.3.5 GPCR Signaling Through mTOR/p70S6K Activation -- 4.4 GPCR-Induced Actin Remodeling and Phosphorylation of Focal Adhesion Proteins -- 4.5 GPCR-Induced Fak Phosphorylation at Tyrosine and Serine Residues -- 4.6 Signaling through Gs, cAMP, PKA, and EPAC -- 4.7 GPCR Signaling Leads to Cell Cycle Activation -- 4.8 Conclusions, Implications, and Emerging Themes -- Acknowledgments -- References -- 5. Transgenic Animal Models of Gastrointestinal Function -- 5.1 Introduction -- 5.2 Generation of Transgenic Mice -- 5.3 Generation of Genetically Engineered Mice by Gene Targeting -- 5.3.1 Gene Knockouts -- 5.3.2 Knock-in Mice -- 5.4 Promoters Used to Study Gastrointestinal Functions -- 5.5 Genetic Mouse Models for Studies of Normal Gastrointestinal Function -- 5.5.1 Esophagus -- 5.5.2 Stomach -- 5.5.3 Intestine -- 5.6 Genetic Mouse Models of Gastrointestinal Diseases -- 5.6.1 Esophagus -- 5.6.2 Stomach -- 5.6.3 Intestine -- 5.7 Conclusion -- References -- 6. Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin -- 6.1 General Overview -- 6.2 Gastrin -- 6.2.1 Overview -- 6.2.2 Gene Structure and Regulation of Expression -- 6.2.3 Prohormone Processing -- 6.2.4 Peptide Sorting -- 6.2.5 Regulation of Peptide Secretion -- 6.2.6 Receptors and Signal Transduction -- 6.2.6.1 Cloning -- 6.2.6.2 Gene Structure -- 6.2.6.3 CCK2 Receptor -- 6.2.6.4 CCK2L Receptor -- 6.2.6.5 CCK2i4sv Receptor -- 6.2.6.6 ΔCCK2 Receptor -- 6.2.6.7 Regulation of CCK2 Receptor Expression -- 6.2.7 Biological and Physiological Actions -- 6.2.7.1 Acid Secretion -- 6.2.7.2 Mucosal Proliferation and Cellular Maturation. , 6.2.7.3 Modulation of Immune Cell Function -- 6.3 Cholecystokinin -- 6.3.1 Overview -- 6.3.2 Gene Structure and Regulation of Expression -- 6.3.3 Prohormone Processing -- 6.3.4 Regulation of Peptide Secretion Release -- 6.3.5 Receptors and Signal Transduction -- 6.3.6 Biological and Physiologic Actions -- 6.3.6.1 Pancreas -- 6.3.6.2 Gallbladder -- 6.3.6.3 Gastric Emptying and Food Intake -- 6.3.6.4 Inflammation -- 6.4 Somatostatin -- 6.4.1 Overview -- 6.4.2 Gene Structure and Regulation of Expression -- 6.4.3 Prohormone Processing -- 6.4.4 Regulation of Peptide Secretion -- 6.4.5 Receptors and Signal Transduction -- 6.4.6 Biological and Physiologic Actions -- 6.4.6.1 Stomach -- 6.4.6.2 Small Bowel -- 6.4.6.3 Colon -- 6.4.6.4 Pancreas -- 6.4.7 Pathological Conditions -- 6.4.7.1 Helicobacter pylori Infection -- 6.4.7.2 Schistosomiasis -- 6.4.7.3 Diabetes Mellitus -- 6.4.7.4 Neuroendocrine Tumors of the GI Tract and Pancreas -- 6.4.7.5 Other Clinical Uses of SST Analogs -- 6.5 Ghrelin -- 6.5.1 Overview -- 6.5.2 Gene Structure and Regulation of Expression -- 6.5.3 Prohormone Processing -- 6.5.4 Regulation of Peptide Secretion -- 6.5.5 Receptors and Signal Transduction -- 6.5.6 Biological and Physiologic Actions -- 6.5.7 Pathological Conditions -- 6.6 Concluding Remarks -- References -- 7. Postpyloric Gastrointestinal Peptides -- 7.1 Secretin -- 7.1.1 Introduction -- 7.1.2 Structure -- 7.1.3 Gastrointestinal Localization of Secretin -- 7.1.4 Secretin Receptor -- 7.1.5 Actions on the Gastrointestinal Tract -- 7.1.6 Regulation of Secretin Secretion -- 7.1.7 Pathobiology of Secretin -- 7.2 Intestinal Somatostatin -- 7.2.1 Gastrointestinal Localization of Somatostatin -- 7.2.2 Somatostatin Receptors -- 7.2.3 Regulation of Somatostatin Secretion -- 7.2.4 Actions on the Gastrointestinal Tract -- 7.3 Vasoactive Intestinal Polypeptide and Related Peptides. , 7.3.1 Introduction -- 7.3.2 Structure -- 7.3.3 Gastrointestinal Localization of VIP -- 7.3.4 VIP Receptors -- 7.3.5 Actions on the Gastrointestinal Tract -- 7.3.6 Regulation of VIP Secretion -- 7.3.7 VIP-related Peptides -- 7.3.7.1 Pituitary Adenylate Cyclase Activating Peptide -- 7.3.7.2 Peptide Histidine Isoleucine/Peptide Histidine Methionine -- 7.4 Neurotensin -- 7.4.1 Introduction -- 7.4.2 Structure -- 7.4.3 Gastrointestinal Localization of Neurotensin -- 7.4.4 Neurotensin Receptors -- 7.4.5 Actions on the Gastrointestinal Tract -- 7.4.6 Regulation of Neurotensin Secretion -- 7.5 Neuropeptide Y -- 7.5.1 Introduction -- 7.5.2 Structure -- 7.5.3 NPY Receptors -- 7.5.4 Gastrointestinal Localization of NPY -- 7.5.5 Secretion -- 7.5.6 Actions on the Gastrointestinal Tract -- 7.6 Motilin -- 7.6.1 Introduction -- 7.6.2 Structure -- 7.6.3 Motilin Receptor -- 7.6.4 Gastrointestinal Localization of Motilin -- 7.6.5 Actions on the Gastrointestinal Tract -- 7.6.6 Mechanism of Action -- 7.6.7 Regulation of Motilin Secretion -- 7.6.8 Pathophysiology -- 7.6.9 Erythromycin and Motilides -- 7.7 Peptide YY -- 7.7.1 Introduction -- 7.7.2 Structure -- 7.7.3 Gastrointestinal Localization of PYY and Developmental Appearance of Intestinal PYY -- 7.7.4 PYY Receptors -- 7.7.5 Actions on the Gastrointestinal Tract -- 7.7.6 Regulation of PYY Secretion -- 7.7.7 Neural Control of PYY Release -- 7.7.8 Trophic Actions of PYY on the Gastrointestinal Tract -- 7.7.9 Inhibitory Action of PYY (3-36) on Appetite and Food Intake and Other Metabolic Actions of PYY -- 7.7.10 Pathophysiology of PYY -- 7.8 Conclusions -- References -- 8. Growth Factors in the Gastrointestinal Tract -- 8.1 Introduction -- 8.1.1 Growth Factors Defined -- 8.1.2 Compartmentalization of Growth Factor Function in the Gastrointestinal Tract -- 8.1.3 "Redundancy" in Growth Factor Families. , 8.2 TGF-β Family of Peptides and Receptors. , English

Additional Edition: ISBN 0-12-382026-X

Language: English

UID:

Format: Online-Ressource

Edition: 5th ed

ISBN: 012382026X , 9780123820266 , 0123820278 , 9780123820273

Content: The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations

Note: Includes bibliographical references and index , Vol. I, section I: Basic cell physiology, genetics, and growth of the GI tract ; section 2. Neurogastroenterology ; Section 3: Host defense mechanisms -- vol. 2, section 4. Physiology of secretion ; section 5. Digestion and absorption ; section 6. Consequences of disregulated physiology. , The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations , Vol. I, section I: Basic cell physiology, genetics, and growth of the GI tract ; section 2. Neurogastroenterology ; Section 3: Host defense mechanismsvol. 2, section 4. Physiology of secretion ; section 5. Digestion and absorption ; section 6. Consequences of disregulated physiology.

Additional Edition: ISBN 012382026X

Additional Edition: ISBN 0123820960

Additional Edition: ISBN 0123820979

Additional Edition: Druckausg. Physiology of the gastrointestinal tract Amsterdam [u.a.] : Elsevier, AP, 2012 ISBN 012382026X

Additional Edition: ISBN 9780123820266

Language: English

Keywords: Verdauungskanal ; Physiologie ; Gastrointestinaltrakt

URL: lizenzpflichtig

URL: Volltext  (An electronic book accessible through the World Wide Web; click for information)

UID:

Format: 29 cm

Edition: 5. ed.

ISBN: 012382026X , 9780123820266

Note: V. I. Sect. I. Basic cell physiology, genetics, and growth of the GI tract. Transcription and epigenetic regulation , Stem cells in the gastrointestinal tract , Innervation of the gastrointestinal tract by spinal and vagal afferent nerves , Neuromuscular physiology of the pelvic floor , Cell physiology of pancreatic ducts , Mechanisms and regulation of intestinal absorption of water-soluble vitamins: cellular and molecular aspects , Mechanisms of helicobacter pylori-induced gastric inflammation , Post-translational processing of gastrointestinal peptides , Genetic tools in gastrointestinal diseases , Signaling pathways induced by G-protein-coupled receptors , Transgenic animal models of gastrointestinal function , Gastrointestinal function , Gastrointestinal peptides: gastrin, cholecystokinin, somatostatin, and ghrelin , Postpyloric gastrointestinal peptides , Growth factors in the gastrointestinal tract , Developmental signaling networks: WNT/[beta]-catenin signaling in the gastrointestinal tract , Hedgehog signaling in gastrointestinal morphogenesis and morphostasis , Notch pathway regulation of intestinal cell fate , Programmed cell death in the gastrointestinal tract , Molecular physiology of gastrointestinal function during development , The cell cycle , Sect. II. Neurogastroenterology. Development of the enteric nervous system , Cellular physiology of gastrointestinal smooth muscle , Organization and electrophysiology of interstitial cells of cajal and smooth muscle cells in the gastrointestinal tract , Enteric nervous system structure and neurochemistry related to function and neuropathology , Physiology of prevertebral sympathetic ganglia , Cellular neurophysiology of enteric neurons , Integrative functions of the enteric nervous system , Processing of gastrointestinal sensory signals in the brain , Neuroimaging of brain-gut interactions in functional gastrointestinal disorders , The neurobiology of gustation: taste buds and transduction processes , Enteric neural regulation of mucosal secretion , Hypothalamic-pituitary-adrenal axis in gastrointestinal physiology , Neural regulation of gastrointestinal blood flow , Neuromuscular function in the biliary tract , Brainstem control of the gastric function , Physiology of aerodigestive reflexes in neonates and adults , Motor function of the pharynx, the esophagus, and its sphincters , Neurophysiologic mechanisms of gastric reservoir function , Physiology of the antral pump and gastric emptying , Neurophysiologic mechanisms of human large intestinal motility , Sect. III. Host defense mechanisms. tight junctions and theintestinal barrier , Biology of gut immunoglobulins , Gastrointestinal microbial ecology with perspectives on health and disease , Mucsoal bacterial recognition and signaling systems in the intestine , Mucosal restitution and repair , Gastroduodenal mucosal defense , V. II. Sect. IV. Physiology of secretion. Paneth cells , Salivary gland secretion , The cell biology of gastric acid secretion , Regulation of gastric acid secretion , Gastroduodenal bicarbonate secretion , Structure-function relationships in the pancreatic acinar cell , Stimulus-secretion coupling in pancreatic acinar cells , Regulation of pancreatic secretion , Bile formation and the enterohepatic circulation , Mechanisms of hepatocyte organic anion transport , Mechanisms of hepatocyte detoxification , Sect. V. Digestion and absorption. Physiology of cholangiocytes , Molecular mechanisms of protein sorting in polarized epithelial cells , Sugar absorption , Protein digestion andabsorption , Enterocyte fatty acid handling proteins and chylomicron formation , Genetic regulation of intestinal lipid transport and metabolism , Digestion and intestinal absorption of dietary carotenoids and vitamin A , 1,25-dihydroxyvitamin D3: synthesis, actions, and genome-scale mechanisms in the intestine and colon /J. Wesley Pike and Mark B. Meyer , Water transport in the gastrointestinal tract , Na+/H+ exchange in mammalian digestive tract , Intestinal antion absorption , cAMP sensor epac and gastrointestinal function , Ion channels of the epithelia of the gastrointestinal tract , Molecular mechanisms of intestinal transport of calcium, phosphate, and magnesium , Molecular mechanisms of intestinal iron transport , Sect. VI. Consequences of disregulated physiology. Trace element absorption and transport , The gastrointestinal tract and control of food intake , Effects of stress on intestinal mucosal functions , Enteric neurobiology of stress , Physiology of host-pathogen interactions , Mechanisms and consequences of intestinal inflammation , Recruitment of inflammatory and immune cells in the gut: physiology and pathophysiology , Mechanisms of GI malignancies /John P. Lynch and Anil K. Rustgi ; Pathophysiology underlying the irritable bowel syndrome , Pathophysiology of diarrhea and its clinical implications

Additional Edition: Erscheint auch als Online-Ausgabe Physiology of the gastrointestinal tract London : Academic Press, 2012 ISBN 012382026X

Additional Edition: ISBN 9780123820266

Additional Edition: ISBN 0123820278

Additional Edition: ISBN 9780123820273

Additional Edition: Erscheint auch als Online-Ausgabe Physiology of the gastrointestinal tract London : Academic Press, 2012 ISBN 012382026X

Additional Edition: ISBN 9780123820266

Additional Edition: ISBN 0123820278

Additional Edition: ISBN 9780123820273

Language: English

Keywords: Verdauungskanal ; Physiologie ; Gastrointestinaltrakt

UID:

ISBN: 0120883945 , 9780120883943 , 9780123820266

Note: Ab 4. Aufl. im Verl. Elsevier, Amsterdam [u.a.] erschienen

Language: English

Subjects: Biology

Keywords: Verdauungskanal ; Physiologie ; Gastrointestinaltrakt ; Physiologie

UID:

ISBN: 0-12-088394-5 , 978-0-12-088394-3 , 978-0-12-382026-6

Note: Ab 4. Aufl. im Verl. Elsevier, Amsterdam [u.a.] erschienen

Language: English

Subjects: Biology

Keywords: Verdauungskanal ; Physiologie ; Gastrointestinaltrakt ; Physiologie