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Format: 1 online resource (541 p.)

Edition: 1st ed.

ISBN: 1-282-95512-8 , 9786612955129 , 0-12-384914-4

Series Statement: Elsevier insights

Content: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neu

Note: Description based upon print version of record. , Front Cover; Neuroinflammation; Copyright Page; Contents; Preface; Contributors; Chapter 1. Multiple Sclerosis: Pathophysiology, Clinical Features, Diagnosis, and Management; Introduction; Epidemiology; Pathophysiology; Clinical Manifestations; Neuroimaging: A Concise Review; Diagnosis; Variants of MS; Differential Diagnosis; Management; Treatment of Acute Relapses; Disease-Modifying Agents; Prognosis; Conclusion; Chapter 2. Epstein-Barr Virus and Multiple Sclerosis: Wrong Place, Wrong Time?; Epstein-Barr Virus; EBV and Diseases; Multiple Sclerosis; Epidemiologic Evidence Linking EBV to MS , EBV Serology and MSIs there a specific EBV Strain causing MS?; Control of EBV Infection by Host Immune Responses; Control of EBV Infection by Virus-Specific CD8+ T Cells; Control of EBV Infection by Virus-Specific CD4+ T Cells; Is EBV a characteristic feature of the MS Brain?; Conclusion; Chapter 3. Neutralizing Antibodies and Multiple Sclerosis; Immunogenicity of Beta-Interferons; Interferon Antibody Assays; Prevalence of NAbs to Beta-Interferons; Interferon Antibody Positivity and Persistence; Clinical Implications of Interferon NAbs; Antibodies to GA; Antibodies to Natalizumab; Conclusion , Chapter 4. Animal Models of Multiple SclerosisEtiology, Clinical Course, and Pathology; Immunology of MS, EAE, and TMEV Infection; Conclusions; Chapter 5. Neuroimaging of Multiple Sclerosis: An Update; Conventional Magnetic Resonance Imaging; Advanced Sequences, New Contrast Agents, High-Field MRI, Quantitative and Nonconventional MRI Techniques; Conclusions; Chapter 6. Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis; Introduction; IL-12 p40 Family; T-Helper-Cell Lineages and Immune Deviation; IL-12 and Th-1 Differentiation Pathways; IL-12 and T-Cell Encephalitogenicity , Myelin-Specific Th-1 Cells in MSIFN-γ in MS/EAE; Genetically Deficient Mice of the p40 Family; The Discovery of IL-23; Critical Role of IL-23 in EAE; IL-23 Expression in CNS; Th-17 Differentiation Pathways; Molecular Mechanisms Regulating Th-17 Pathway; The Plasticity of Th-17 Cells; In Vitro Differentiation of Encephalitogenic Th-17 Cells; Human Th-17 Cells; Distinct Type of Inflammation Induced by Th-1 or Th-17 Cells; Anti-p40 Therapy; T-bet: A Potential Prognostic Marker and Therapeutic Target in MS , Chapter 7. Spinal Cord Injury and its Relationship to the Development or Worsening of Clinical Multiple SclerosisIntroduction; Historical Review; Relationships of Plaques to Blood Vessels; Breakdown of the BBB in Plaque Formation; Inflammatory Cell Infiltrates; Astrocytic and Other Cellular Changes; Effect of Trauma on the BBB; Studies of Stress on the BBB; Studies Showing that the Site of the BBB Breakdown is related to the Formation of New Demyelinating Plaques; Effect of Electrical Injuries in the Precipitation or Worsening of MS , Therapeutic Trials of Breaking Down the BBB in Patients with MS , English

Additional Edition: ISBN 0-12-384913-6

Language: English

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Format: Online-Ressource

Edition: Online-Ausg. Amsterdam Elsevier Science & Technology 2010 Electronic reproduction; Mode of access: World Wide Web

ISBN: 0123849136 , 9780123849137

Content: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Content: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Note: Description based upon print version of record , Multiple Sclerosis -- Optic neuritis -- Transverse myelitis -- Ischemic demyelination -- Acute disseminated encephalomyelitis -- Neurosarcoidosis -- Balo concentric sclerosis -- Neuromyelitis optica (Devic's disease) -- Necrotizing myelopathy -- Susac syndrome -- Central nervous system vasculitis -- Neuropsychiatric SLE -- Progressive multifocal leukoencephalopathy -- Antiphospholipid antibody syndrome -- Current treatments for multiple sclerosis. , Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities , Electronic reproduction; Mode of access: World Wide Web

Additional Edition: ISBN 0123849136

Additional Edition: Erscheint auch als Druck-Ausgabe Neuroinflammation

Language: English

Keywords: Electronic books

URL: Volltext  (An electronic book accessible through the World Wide Web; click for information)

URL: lizenzpflichtig

UID:

Edition: 2010

ISBN: 9780123849137 , 0123849136

Language: English

URL: Volltext